2-Phenylbenzyl chloride

Base Information

• Chemical Name: 2-Phenylbenzyl chloride
• CAS No.: 38580-83-5
• Molecular Formula: C13H11Cl
• Molecular Weight: 202.683
• Hs Code.: 2903999090
• Mol file: 38580-83-5.mol

Synonyms:1-(chloromethyl)-2-phenylbenzene;

Chemical Property of 2-Phenylbenzyl chloride

Chemical Property:

• Boiling Point: 334℃
• Flash Point: 150℃
• PSA: 0.00000
• Density: 1.111
• LogP: 4.09240
• Storage Temp.: 2-8°C

Purity/Quality:

99%min ^*data from raw suppliers

2-(Chloromethyl)biphenyl 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Phenylbenzyl chloride

There total 13 articles about 2-Phenylbenzyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-bromobenzylchloride (578-51-8) + phenylboronic acid (98-80-6) → 2-phenylbenzyl chloride (38580-83-5)

Guidance literature:

With palladium diacetate; caesium carbonate; tricyclohexylphosphine tetrafluoroborate; In water; toluene; at 80 ℃; for 2h; Schlenk technique; Inert atmosphere;

DOI:10.3390/molecules23020433

Reference yield: 96.9%

2-methylbiphenyl (643-58-3) → 2-phenylbenzyl chloride (38580-83-5)

Guidance literature:

With tetrachloromethane; sulfuryl dichloride; 2,2'-azobis(isobutyronitrile); at 70 ℃; for 2h;

Reference yield: 82.0%

2-biphenylmethanol (2928-43-0) → 2-phenylbenzyl chloride (38580-83-5)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 20 ℃; for 3.3h; regioselective reaction;

DOI:10.1021/ja3116718

upstream raw materials:

2-biphenylmethanol

2-methylbiphenyl

biphenyl-2-carboxylic acid methyl ester

2-(chloromethyl)iodobenzene

Downstream raw materials:

1,2-bis(biphenyl-2-yl)ethane

methyl 4-([{1,1’-biphenyl}-2-yl]methoxy)benzoate

2-(7-methyl-2-methyleneoct-6-enyl)biphenyl

C₂₄H₁₉ClN₂O₃

Refernces

• 1、 Heitel, Pascal,Gellrich, Leonie,Kalinowsky, Lena,Heering, Jan,Kaiser, Astrid,Ohrndorf, Julia,Proschak, Ewgenij,Merk, Daniel. "Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype". supporting information. p. 203 - 208. Retrieved 2019/01/25.
• 2、 Pei, Ming-ming,Liu, Ping,Liu, Yan,Lv, Xin-ming,Ma, Xiao-wei,Dai, Bin. "Pd-catalyzed, highly selective C(sp2)-Br bond coupling reactions of o-(or m-, or p-) chloromethyl bromobenzene with arylboronic acids". . . Retrieved 2018/02/27.