1-(Piperidin-4-ylcarbonyl)piperidine

Base Information

• Chemical Name: 1-(Piperidin-4-ylcarbonyl)piperidine
• CAS No.: 63214-58-4
• Molecular Formula: C11H20N2O
• Molecular Weight: 196.293
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID80383323
• Wikidata: Q82174989
• Mol file: 63214-58-4.mol

Synonyms:1-(piperidin-4-ylcarbonyl)piperidine;63214-58-4;piperidin-1-yl(piperidin-4-yl)methanone;(Piperidin-1-yl)(Piperidin-4-yl)methanone;Piperidin-4-yl-piperidin-1-yl-methanone;piperidino(4-piperidinyl)methanone;1-(piperidine-4-carbonyl)piperidine;4-(piperidine-1-carbonyl)piperidine;Methanone,1-piperidinyl-4-piperidinyl-;Oprea1_737684;SCHEMBL3156620;DTXSID80383323;HMS1734G04;HMS3442J02;MFCD03372500;STK100030;Piperidin-1-ylpiperidin-4-ylmethanone;piperidin-4-ylpiperidin-1-ylmethanone;AKOS000199878;CCG-134821;PS-3548;SB41267;piperidine, 1-(4-piperidinylcarbonyl)-;Piperidin-1-yl-piperidin-4-yl-methanone;BB 0220151;CS-0206063;FT-0681473;EN300-57524;A868209;J-502085;Z139720798

Chemical Property of 1-(Piperidin-4-ylcarbonyl)piperidine

Chemical Property:

• Vapor Pressure: 4.37E-05mmHg at 25°C
• Refractive Index: 1.505
• Boiling Point: 350.5 °C at 760 mmHg
• PKA: 10.05±0.10(Predicted)
• Flash Point: 165.8 °C
• PSA: 32.34000
• Density: 1.047 g/cm³
• LogP: 1.26520
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 196.157563266
• Heavy Atom Count: 14
• Complexity: 194

Purity/Quality:

99% ^*data from raw suppliers

1-(Piperidin-4-ylcarbonyl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,Xi
• Hazard Codes: C,Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C(=O)C2CCNCC2

Technology Process of 1-(Piperidin-4-ylcarbonyl)piperidine

There total 5 articles about 1-(Piperidin-4-ylcarbonyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-(piperidine-1-carbonyl)-piperidine-1-carboxylic acid tert-butyl ester (757949-38-5) → piperidin-4-yl-piperidin-1-yl-methanone (63214-58-4)

Guidance literature:

4-(piperidine-1-carbonyl)-piperidine-1-carboxylic acid tert-butyl ester; With hydrogenchloride; In water; at 0 ℃; for 0.166667h;

With sodium hydroxide; In water; pH=10;

Reference yield:

4-(Piperidine-1-carbonyl)-piperidine-1-carboxylic acid benzyl ester (147635-70-9) → piperidin-4-yl-piperidin-1-yl-methanone (63214-58-4)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; under 760 Torr; Ambient temperature;

DOI:10.1021/jm00364a014

Reference yield:

piperidin-1-yl(pyridin-4-yl)methanone (4968-87-0) → piperidin-4-yl-piperidin-1-yl-methanone (63214-58-4)

Guidance literature:

With hydrogenchloride; hydrogen; In methanol; under 760 Torr; Ambient temperature;

DOI:10.1021/jm00364a014

upstream raw materials:

piperidin-1-yl(pyridin-4-yl)methanone

4-(Piperidine-1-carbonyl)-piperidine-1-carboxylic acid benzyl ester

4-(piperidine-1-carbonyl)-piperidine-1-carboxylic acid tert-butyl ester

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

Downstream raw materials:

4-piperidin-1-ylmethyl-piperidine-1-carboxylic acid (4-bromo-phenyl)amide

(1-(4-(6-(6-amino-5-trifluoromethylpyridin-3-yl)imidazo[1,2-b]pyridazin-3-yl)benzyl)piperidin-4-yl)piperidin-1-ylmethanone

4-(4-(piperidine-1-ylcarbonyl)piperidin-1-ylmethyl)phenylboronic acid

4-(piperidin-1-yl)methyl-piperidine

Refernces

• 1、 Nencini, Arianna,Castaldo, Cristiana,Comery, Thomas A.,Dunlop, John,Genesio, Eva,Ghiron, Chiara,Haydar, Simon,Maccari, Laura,Micco, Iolanda,Turlizzi, Elisa,Zanaletti, Riccardo,Zhang, Jean. "Design and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor". . p. 401 - 418. Retrieved 2014/04/17.
• 2、 -. "MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF". Page/Page column 21. . Retrieved 2008/06/13.