N-formylmethamphetamine

Base Information

• Chemical Name: N-formylmethamphetamine
• CAS No.: 42932-20-7
• Molecular Formula: C11H15 N O
• Molecular Weight: 177.246
• Hs Code.: 2924299090
• Mol file: 42932-20-7.mol

Synonyms:1-Phenyl-2-(N-methyl-N-formylamino)propane;Formyl-N,a-dimethyl-2-phenylethylamine;N-Formylmethamphetamine; N-Methyl-N-(a-methylphenylethyl)formamide

Chemical Property of N-formylmethamphetamine

Chemical Property:

• Vapor Pressure: 0.000231mmHg at 25°C
• Boiling Point: 325.4°Cat760mmHg
• Flash Point: 121.7°C
• PSA: 20.31000
• Density: 1.002g/cm³
• LogP: 2.34170

Purity/Quality:

98% ^*data from raw suppliers

N-Formylmethamphetamine ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An impurity of Methamphetamine (M258795). Controlled substance.

Technology Process of N-formylmethamphetamine

There total 10 articles about N-formylmethamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(2S,4S)-3,4-dimethyl-5-phenyl-1,3-oxazolidine (1668-82-2,211676-69-6) → N-formylmethamphetamine (42932-20-7,26343-75-9,894793-16-9)

Guidance literature:

5percent Pd/C; In cyclohexane; at 80 ℃; for 24h;

DOI:10.1039/b010089g

Reference yield: 69.0%

methylamine hydrochloride (593-51-1) + 1-phenyl-acetone (103-79-7,136675-26-8) → methamphetamin (7632-10-2) + 2,6-dimethyl-3,5-diphenylpyridine (65907-81-5) + 3-phenyl-2-propanol (698-87-3,14898-87-4) + N-benzoylmethamphetamine (73355-87-0) + N-(1-methyl-2-phenylethyl)benzamide (70631-05-9,1795-95-5) + N-acetylmethamphetamine (27765-80-6) + N-formylmethamphetamine (42932-20-7,26343-75-9,894793-16-9) + N-(β-phenylisopropyl)benzyl(methyl)ketimine (74917-80-9) + 2-amino-1-phenylpropane (60-15-1,156-34-3,51-64-9,300-62-9,17108-96-2,96332-84-2) + 3,4-diphenylbut-3-en-2-one (1722-69-6)

Guidance literature:

With aluminum amalgam; sodium hydroxide; In methanol; at -10 - 60 ℃; for 1.5h;

DOI:10.1021/ac9005588

Reference yield:

-(5-phenyl-2-furylmethyl)-amin (102732-71-8) → methamphetamin (7632-10-2) + 2-phenylfuran (17113-33-6) + N-formylmethamphetamine (42932-20-7,26343-75-9,894793-16-9) + bis(5-phenylfuran-2-yl)methane + 5--1-phenyl-pentan-1,4-dion

Guidance literature:

With hydrogenchloride; for 28h; Rate constant; Heating; t1/2;

DOI:10.1002/ardp.19863190406

upstream raw materials:

methamphetamin

methanol

-(5-phenyl-2-furylmethyl)-amin

<5-(4-Chlorphenyl)-2-furylmethyl>-methyl-(1-methyl-2-phenyl-ethyl)-amin

Downstream raw materials:

methamphetamin

Refernces

• 1、 Kunalan, Vanitha,Daeid, Niamh Nic,Kerr, William J.,Buchanan, Hilary A. S.,McPherson, Allan R.. "Characterization of route specific impurities found in methamphetamine synthesized by the Leuckart and reductive amination methods". experimental part. p. 7342 - 7348. Retrieved 2010/04/06.
• 2、 Alexakis,Aujard,Pytkowicz,Roland,Mangeney. "Unusually facile palladium catalysed oxidation of imidazolidines and oxazolidines". . p. 949 - 951. Retrieved 2007/10/03.