Pyrazin-2-ylmethanol

Base Information

• Chemical Name: Pyrazin-2-ylmethanol
• CAS No.: 6705-33-5
• Molecular Formula: C5H6N2O
• Molecular Weight: 110.115
• Hs Code.: 2933990090
• European Community (EC) Number: 691-621-1
• UNII: C27Z7QI77D
• DSSTox Substance ID: DTXSID00217338
• Nikkaji Number: J2.263.475E
• Wikidata: Q27275091
• Mol file: 6705-33-5.mol

Synonyms:2-Pyrazinylmethanol;6705-33-5;pyrazin-2-ylmethanol;Pyrazinemethanol;(pyrazin-2-yl)methanol;(2-Hydroxymethyl)pyrazine;2-PYRAZINEMETHANOL;Pyrazin-2-yl-methanol;2-Hydroxymethylpyrazine;2-(Hydroxymethyl)pyrazine;BRN 0110057;PYRAZINE-2-METHANOL;UNII-C27Z7QI77D;C27Z7QI77D;MFCD01693938;pyrazin-2-yl methanol;(HYDROXYMETHYL)PYRAZINE;SCHEMBL284256;2-pyrazinylmethanol, AldrichCPR;DTXSID00217338;BCP23157;AKOS009358705;CS-W018634;PB21779;PS-3553;BL002777;BP-11245;SY004183;LS-127617;AM20070379;FT-0684700;P2129;EN300-81801;A835617;J-510304;Q27275091

Chemical Property of Pyrazin-2-ylmethanol

Chemical Property:

• Vapor Pressure: 0.0339mmHg at 25°C
• Melting Point: 38.5 °C
• Refractive Index: 1.557
• Boiling Point: 231.9 °C at 760 mmHg
• PKA: 13.48±0.10(Predicted)
• Flash Point: 94.1 °C
• PSA: 46.01000
• Density: 1.227 g/cm³
• LogP: -0.03110
• Storage Temp.: 2-8°C
• XLogP3: -1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 110.048012819
• Heavy Atom Count: 8
• Complexity: 67.4

Purity/Quality:

99% ^*data from raw suppliers

2-Pyrazinylmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-24/25-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C=N1)CO

Technology Process of Pyrazin-2-ylmethanol

There total 2 articles about Pyrazin-2-ylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethylenediamine (107-15-3,85404-18-8) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 1,4-pyrazine (290-37-9) + 2-Methylpyrazine (109-08-0) + 2,5-dimethyl-pyrazine (123-32-0) + 2,3-dimethylpyrazine (5910-89-4) + pyrazin-2-ylmethanol (6705-33-5) + 2,6-dimethylpyrazine (108-50-9) + pyrazinecarboxaldehyde (5780-66-5)

Guidance literature:

In water; at 375 ℃; for 6h; under 760.051 Torr; Inert atmosphere; Flow reactor;

DOI:10.1134/S0023158416050177

Reference yield:

ethylenediamine (107-15-3,85404-18-8) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 2-Methylpyrazine (109-08-0) + pyrazin-2-ylmethanol (6705-33-5)

Guidance literature:

With oxygen; zinc(II) oxide; In water; Kinetics;

DOI:10.1016/j.apcata.2013.10.023

Reference yield: 100.0%

pyrazin-2-ylmethanol (6705-33-5) → 2-(chloromethyl)pyrazine (39204-47-2)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

upstream raw materials:

ethylenediamine

glycerol

Downstream raw materials:

pyrazinecarboxaldehyde

4-{[(2-pyrazinyl)methyl]sulfanyl}aniline

7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(2-pyrazinyl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

[6-(pyrazin-2-ylmethoxy)-pyridin-3-yl]-carbamic acid phenyl ester

Refernces

• 1、 Venugopal, Akula,Sarkari, Reema,Anjaneyulu, Chatla,Krishna, Vankudoth,Kumar, Mandari Kotesh,Narender, Nama,Padmasri, Aytam Hari. "Influence of acid-base sites on ZnO-ZnCr2O4 catalyst during dehydrocyclization of aqueous glycerol and ethylenediamine for the synthesis of 2-methylpyrazine: Kinetic and mechanism studies". . p. 398 - 409. Retrieved 2013/11/19.