Tricetin

Base Information

• Chemical Name: Tricetin
• CAS No.: 520-31-0
• Molecular Formula: C15H10O7
• Molecular Weight: 302.24
• Hs Code.: 2914501900
• European Community (EC) Number: 809-455-7
• UNII: 5627PY99ZO
• ChEMBL ID: CHEMBL247484
• DSSTox Substance ID: DTXSID60199964
• Metabolomics Workbench ID: 23930
• Nikkaji Number: J11.687D
• RXCUI: 1994358
• Wikidata: Q15303946
• Wikipedia: Tricetin
• Mol file: 520-31-0.mol

Synonyms:5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one;tricetin

Chemical Property of Tricetin

Chemical Property:

• Vapor Pressure: 1.61E-21mmHg at 25°C
• Melting Point: >330 °C (decomp)
• Refractive Index: 1.804
• Boiling Point: 721.7 °C at 760 mmHg
• PKA: 6.48±0.40(Predicted)
• Flash Point: 277.9 °C
• PSA: 131.36000
• Density: 1.763 g/cm³
• LogP: 1.98800
• XLogP3: 1
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 1
• Exact Mass: 302.04265265
• Heavy Atom Count: 22
• Complexity: 465

Purity/Quality:

99%, ^*data from raw suppliers

5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(C(=C1O)O)O)C2=CC(=O)C3=C(C=C(C=C3O2)O)O

Technology Process of Tricetin

There total 17 articles about Tricetin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5,7-Dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one (53350-26-8) → tricetin (520-31-0)

Guidance literature:

With pyridine hydrochloride; at 240 - 245 ℃; for 0.833333h;

Reference yield: 38.0%

5,7-dihydroxy-3',4',5'-trimethoxyflavone (18103-42-9) → tricetin (520-31-0)

Guidance literature:

With hydrogen bromide; In acetic acid; for 23h; Heating;

DOI:10.3390/12010086

Reference yield: 10.0%

4,6-bis(methoxymethyl)-2-(3,4,5-triacetoxybenzoyloxy)acetophenone → tricetin (520-31-0)

Guidance literature:

4,6-bis(methoxymethyl)-2-(3,4,5-triacetoxybenzoyloxy)acetophenone; With potassium hydroxide; In pyridine; at 50 ℃; for 0.333333h;

With acetic acid; In pyridine; water; for 0.5h;

With hydrogenchloride; In methanol; Reflux;

DOI:10.2174/1570178611999140206115633

upstream raw materials:

5,7-dihydroxy-3',4',5'-trimethoxyflavone

2,4,6-trihydroxyacetophenone

3,4,5-trimethoxybenzoic anhydride

3,4,5-trimethoxybenzoic acid methyl ester

Downstream raw materials:

5,7,4'trihydroxy-3',5'-dimethoxyflavone

Refernces

• 1、 -. "Preparation method and application of tricetin". . . Retrieved 2019/10/01.
• 2、 Gao, Hong,Nishida, Jun,Saito, Shizuka,Kawabata, Jun. "Inhibitory effects of 5,6,7-trihydroxyflavones on tyrosinase". . p. 86 - 97. Retrieved 2008/02/04.