5-hydroxy-7,8-dimethoxyflavone

Base Information

• Chemical Name: 5-hydroxy-7,8-dimethoxyflavone
• CAS No.: 3570-62-5
• Molecular Formula: C17H14 O5
• Molecular Weight: 298.295
• Hs Code.: 2914509090
• Mol file: 3570-62-5.mol

Synonyms:Flavone,5-hydroxy-7,8-dimethoxy- (6CI,7CI,8CI); 5-Hydroxy-7,8-dimethoxyflavone;7,8-Dimethoxy-5-hydroxyflavone; 7,8-Dimethoxynorwogonin; 7-O-Methylwogonin;7-O-Methylwogonine; Moslosooflavone

Chemical Property of 5-hydroxy-7,8-dimethoxyflavone

Chemical Property:

• Vapor Pressure: 5.67E-12mmHg at 25°C
• Melting Point: 182-183℃
• Boiling Point: 532.9oC at 760 mmHg
• PKA: 6.83±0.40(Predicted)
• Flash Point: 200.6oC
• PSA: 68.90000
• Density: 1.321g/cm3
• LogP: 3.18280
• Storage Temp.: 2-8°C

Purity/Quality:

≥98% ^*data from raw suppliers

Moslosooflavone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-hydroxy-7,8-dimethoxyflavone

There total 22 articles about 5-hydroxy-7,8-dimethoxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5,7,8-trimethoxy-2-phenyl-chromen-4-one (23050-38-6) → 5-hydroxy-7,8-dimethoxyflavone (3570-62-5)

Guidance literature:

With aluminum (III) chloride; In acetonitrile; at 0 - 70 ℃; for 8h; Temperature; Inert atmosphere;

Reference yield: 82.0%

wogonin (632-85-9) + methyl iodide (74-88-4) → 5-hydroxy-7,8-dimethoxyflavone (3570-62-5)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; Inert atmosphere;

DOI:10.1002/cbdv.201400181

Reference yield: 80.5%

8-Brom-5-acetoxy-7-methoxy-flavon (93869-48-8) + sodium methylate (124-41-4) → 5-hydroxy-7,8-dimethoxyflavone (3570-62-5) + mosloflavone (740-33-0)

Guidance literature:

sodium methylate; With copper(I) bromide; In methanol; N,N-dimethyl-formamide; at 20 ℃; for 1h;

8-Brom-5-acetoxy-7-methoxy-flavon; In methanol; N,N-dimethyl-formamide; at 120 ℃; for 5h;

With hydrogenchloride; In methanol; water; N,N-dimethyl-formamide; at 20 ℃; Cooling;

DOI:10.1016/j.tet.2009.12.021

upstream raw materials:

diazomethane

wogonin

norwogonin

sodium methylate

Downstream raw materials:

5,7-dihydroxy-6-formyl-8-methoxyflavone

I(5),II(5)-dihydroxy-I(7),II(7),I(8),II(8)-tetramethoxyhomobiflavone

5,8-dihydroxy-7-methoxyflavone

5-Acetoxy-7,8-dimethoxy-flavon

Refernces

• 1、 Wang, Qi,Terreaux, Christian,Marston, Andrew,Tan, Ren Xiang,Stoeckli-Evans, Helen,Hostettmann, Kurt. "A new 2-hydroxyflavanone from Mosla soochouensis". . p. 729 - 731. Retrieved 1999.
• 2、 -. "[...] flavone, [...] baicalin and to a method for synthesizing Chinese baicalin". Paragraph 0040-0042; 0043-0045; 0046-0048. . Retrieved 2018/09/08.
• 3、 Wang, Shao-Hung,Chen, Ching-Hsein,Lo, Chih-Yu,Feng, Ji-Zhen,Lin, Hong-Jhih,Chang, Po-Ya,Yang, Ling-Ling,Chen, Lih-Geeng,Liu, Yi-Wen,Kuo, Cheng-Deng,Wu, Jin-Yi. "Synthesis and biological evaluation of novel 7-O-lipophilic substituted baicalein derivatives as potential anticancer agents". supporting information. p. 1864 - 1873. Retrieved 2015/10/20.