1,6-DIPHENYLHEXANE

Base Information

• Chemical Name: 1,6-DIPHENYLHEXANE
• CAS No.: 1087-49-6
• Molecular Formula: C18H22
• Molecular Weight: 238.373
• Hs Code.: 2902909090
• Mol file: 1087-49-6.mol

Synonyms:Hexane,1,6-diphenyl- (6CI,8CI); 1,6-Diphenylhexane; NSC 44143

Chemical Property of 1,6-DIPHENYLHEXANE

Chemical Property:

• Melting Point: -2.45°C
• Refractive Index: 1.5500 (estimate)
• Boiling Point: 367.1°Cat760mmHg
• Flash Point: 190°C
• PSA: 0.00000
• Density: 0.957g/cm³
• LogP: 5.03220

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,6-DIPHENYLHEXANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,6-DIPHENYLHEXANE

There total 91 articles about 1,6-DIPHENYLHEXANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

phenylmagnesium bromide + 6-bromohexyl 4-methylbenzenesulfonate → 1,6-diphenylhexane (1087-49-6) + (6-bromohexyl)benzene (27976-27-8)

Guidance literature:

With buta-1,3-diene; palladium(II) acetylacetonate; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1246/cl.2003.890

Reference yield: 65.3%

4-iodobutyl acetate (40596-44-9) + 3-phenylpropylmagnesium bromide (1462-75-5) → 7-phenylheptan-1-ol (3208-25-1) + phenylpropane (103-65-1) + 1,6-diphenylhexane (1087-49-6) + 1-acetoxy-7-phenylheptane (155446-29-0)

Guidance literature:

With methylmagnesium bromide; lithium chloride; copper dichloride; In tetrahydrofuran; at 25 ℃; for 1h;

DOI:10.1080/00397919408020770

Reference yield: 49.0%

1-Bromo-3-phenylpropane (637-59-2) + bis(pinacol)diborane (73183-34-3) → phenylpropane (103-65-1) + 1,6-diphenylhexane (1087-49-6) + 4,4,5,5-tetramethyl-2-(3-phenylpropyl)-[1,3,2]dioxaborolane (329685-40-7)

Guidance literature:

With chlorotris(triphenylphosphine)cobalt(I); sodium ethanolate; 1,3-bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene; In toluene; at 50 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00038

upstream raw materials:

1 ,6-dibromohexane

bromobenzene

1,4-dibenzoylbutane

1,6-diphenyl-hexa-1,3,5-triene

Downstream raw materials:

1,6-dicyclohexylhexane

dodecafluoro-1,6-bis-undecafluorocyclohexyl-hexane

1,6-bis-(4-propionyl-phenyl)-hexane

C₂₀H₂₄Br₂

Refernces

• 1、 Sheng, Jie,Ni, Hui-Qi,Ni, Shan-Xiu,He, Yan,Cui, Ru,Liao, Guang-Xu,Bian, Kang-Jie,Wu, Bing-Bing,Wang, Xi-Sheng. "Diversity-Oriented Synthesis of Aliphatic Fluorides via Reductive C(sp3)?C(sp3) Cross-Coupling Fluoroalkylation". . p. 15020 - 15027. Retrieved 2021.
• 2、 Jones, Gavin D.,McFarland, Chris,Anderson, Thomas J.,Vicic, David A.. "Analysis of key steps in the catalytic cross-coupling of alkyl electrophiles under Negishi-like conditions". . p. 4211 - 4213. Retrieved 2005.
• 3、 Ravn, Anne K.,Johansen, Martin B.,Skrydstrup, Troels. "Regioselective Hydroalkylation of Vinylarenes by Cooperative Cu and Ni Catalysis". supporting information. . Retrieved 2021/12/14.
• 4、 Siddiqui, Sheema,Bhawar, Ramesh,Geetharani. "Iron-Based Catalyst for Borylation of Unactivated Alkyl Halides without Using Highly Basic Organometallic Reagents". supporting information. p. 1948 - 1954. Retrieved 2021/01/14.