2-Nitrofuran

Base Information

• Chemical Name: 2-Nitrofuran
• CAS No.: 609-39-2
• Molecular Formula: C4H3 N O3
• Molecular Weight: 113.073
• European Community (EC) Number: 625-946-7
• NSC Number: 59983
• UNII: 17EZI4D981
• DSSTox Substance ID: DTXSID80870682
• Nikkaji Number: J489H
• Wikidata: Q27116311
• Metabolomics Workbench ID: 55043
• Mol file: 609-39-2.mol

Synonyms:2-NITROFURAN;609-39-2;Nitrofuran;5-Nitrofuran;Furan, 2-nitro-;Furan, nitro-;Nitrofuran (VAN);AI3-23606;NSC 59983;BRN 0112523;UNII-17EZI4D981;27194-24-7;17EZI4D981;NSC-59983;5-17-01-00296 (Beilstein Handbook Reference);2-Nitrofurane;2-Nitrofuran, 97%;SCHEMBL30623;CHEBI:34890;DTXSID80870682;BCP23236;NSC59983;AKOS015900364;LS-70264;AM20100483;FT-0632538;EN300-139040;Q-103253;Q27116311;2-nitro-fura

Chemical Property of 2-Nitrofuran

Chemical Property:

• Appearance/Colour: solid
• Melting Point: 29-33 °C(lit.)
• Refractive Index: 1.4543 (estimate)
• Boiling Point: 84 °C13 mm Hg(lit.)
• Flash Point: 88 C (closed cup)
• PSA: 58.96000
• Density: 1.5808 (rough estimate)
• LogP: 1.71100
• Storage Temp.: 2-8°C
• Solubility.: Chloroform, Methanol
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 113.011292958
• Heavy Atom Count: 8
• Complexity: 97.9

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Nitrofuran ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-40
• Safety Statements: 7-23-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=COC(=C1)[N+](=O)[O-]
• Uses: 2-NITROFURAN is a minor antimicrobial used in veterinary medicine. Nitrofurans are a class of broad-spectrum antibacterial compounds that are commonly added to water to destroy bacteria. However, nitrofurans have recently been withdrawn for use in the United States by the US Food and Drug Administration (FDA). Now, 2-nitrofuran is used as a minor antimicrobial in veterinary medicine.

Technology Process of 2-Nitrofuran

There total 6 articles about 2-Nitrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.0%

2-furyltrimethylsilane (1578-33-2) → 2-nitrofuran (609-39-2) + trimethyl(5-nitro-2-furyl)silane (120823-76-9)

Guidance literature:

With nitronium tetrafluoborate; In acetonitrile; at -40 ℃; for 1h;

DOI:10.1016/0022-328X(88)80334-6

Reference yield:

2-furanoic acid (88-14-2) → 2-nitrofuran (609-39-2) + 5-nitro-2-furoic acid (645-12-5)

Guidance literature:

With nitric acid; acetic anhydride;

Reference yield:

2-furanoic acid (88-14-2) + nitric acid (7697-37-2,78989-43-2) + acetic anhydride (108-24-7) → 2-nitrofuran (609-39-2) + 5-nitro-2-furoic acid (645-12-5)

Guidance literature:

at -10 ℃;

upstream raw materials:

1-(2-furyl)-1-ethanone

acetic anhydride

2-furanoic acid

2-furyltrimethylsilane

Downstream raw materials:

2-nitro-5-furyl ethyl ketone

2-nitro-5-phenoxyfuran

2-(4-methoxyphenoxy)-5-nitrofuran

3-[(5-nitrofuran-2-yl)oxy]benzonitrile

Refernces