1-Propanamine, 3-azido-

Base Information

• Chemical Name: 1-Propanamine, 3-azido-
• CAS No.: 88192-19-2
• Molecular Formula: C3H8N4
• Molecular Weight: 100.123
• Hs Code.: 2929909090
• Mol file: 88192-19-2.mol

Synonyms:(3-Azidopropyl)amine;1-Amino-3-azidopropane;3-Aminopropyl azide;

Chemical Property of 1-Propanamine, 3-azido-

Chemical Property:

• Melting Point: 47-49 °C
• Refractive Index: n20/D1.471
• Boiling Point: 50°C/15mmHg(lit.)
• Flash Point: 60°(140°F)
• PSA: 75.77000
• Density: 1.020 g/mL at 25 °C
• LogP: 0.79856
• Storage Temp.: ?20°C
• Water Solubility.: Soluble in DMSO, DMF, DCM, chloroform, THF, and water.Miscible with dimethylsulfoxide, dimethyl formamide, dichloromethane, tetr

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Azidopropylamine >95.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Azido-containing reagent with carbonyl and carboxyl reactivity3-Azido-1-propylamine is used in the preparation of perylenedimides derivative by reacting with 1,6,7,12-tetrachloroperylene-3,4:9,10-tetracarboxyanhydride, which is used in click chemistry. Amine modified azide for click chemistry.

Technology Process of 1-Propanamine, 3-azido-

There total 19 articles about 1-Propanamine, 3-azido- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-chloropropylamine hydrochloride (6276-54-6) → 3-azidopropylamine (88192-19-2)

Guidance literature:

With sodium azide; In water; at 80 ℃; for 15h;

DOI:10.3390/molecules22050802

Reference yield: 99.0%

tert-butyl N-(3-azidopropyl)carbamate (129392-84-3) → 3-azidopropylamine (88192-19-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 96.0%

3-bromopropylamine hydrochloride (5003-71-4) → 3-azidopropylamine (88192-19-2)

Guidance literature:

3-bromopropylamine hydrochloride; With sodium azide; In water; for 16h; Reflux;

With potassium hydroxide; In diethyl ether; water; at 10 ℃;

DOI:10.1021/acs.orglett.5b00069

upstream raw materials:

(3-azido-propyl)-carbamic acid ethyl ester

3-chloropropylamine hydrochloride

1-azido-3-isocyanatopropane

1,3-diazido-propane

Downstream raw materials:

N-phenyl-1,3-propanediamine dihydrochloride

1,3-diaminopropane dihydrochloride

Trimethylenediamine

tert-butyl N-(3-azidopropyl)carbamate

Refernces

• 1、 Vollrath, Sidonie B. L.,Fuerniss, Daniel,Schepers, Ute,Braese, Stefan. "Amphiphilic peptoid transporters-synthesis and evaluation". . p. 8197 - 8201. Retrieved 2013.
• 2、 Cantrell, William,Huang, Yue,Menchaca, Antonio A.,Kulik, George,Welker, Mark E.. "Synthesis and PI3 kinase inhibition activity of a Wortmannin-Leucine derivative". . . Retrieved 2018.
• 3、 Liu, Wei,Dong, Chang-Ming. "Versatile synthesis of asymmetrical dendron-like/dendron-like poly(ε-caprolactone)-b-poly(γ-benzyl- L -glutamate) block copolymers". . p. 3491 - 3498. Retrieved 2011.
• 4、 Yu, Yanwen,Li, Yongjun,Chen, Songhua,Liu, Taifeng,Qin, Zhihong,Liu, Huibiao,Li, Yuliang. "Synthesis of a naphthalene-diimide cyclophane for tuning supramolecular interactions by metal ions". . p. 4287 - 4292. Retrieved 2012.
• 5、 Sarkar, Kishor,Madras, Giridhar,Chatterjee, Kaushik. "Dendron conjugation to graphene oxide using click chemistry for efficient gene delivery". . p. 50196 - 50211. Retrieved 2015.
• 6、 Cui, Jiabin,Jiang, Rui,Guo, Chang,Bai, Xilin,Xu, Suying,Wang, Leyu. "Fluorine Grafted Cu7S4-Au Heterodimers for Multimodal Imaging Guided Photothermal Therapy with High Penetration Depth". . p. 5890 - 5894. Retrieved 2018.
• 7、 Molina, Noemi,Nájera, Francisco,Guadix, Juan A.,Perez-Pomares, Jose M.,Vida, Yolanda,Perez-Inestrosa, Ezequiel. "Synthesis of Amino Terminal Clicked Dendrimers. Approaches to the Application as a Biomarker". . p. 10197 - 10208. Retrieved 2019.
• 8、 Yan, Qin,Zheng, Hong-Ning,Jiang, Chuan,Li, Kun,Xiao, Shou-Jun. "EDC/NHS activation mechanism of polymethacrylic acid: Anhydride versus NHS-ester". . p. 69939 - 69947. Retrieved 2015.
• 9、 -. "Sulfonamide rhodamine compound with alkynyl group or azido group derived positions as well as preparation method and application thereof". Paragraph 0022-0024. . Retrieved 2021/06/21.
• 10、 -. "Novel diagnosis and treatment type nano-drug based on molecular shuttle". Paragraph 0101-0106. . Retrieved 2020/05/01.