3-FLUORO-4-IODOANISOLE

Base Information

• Chemical Name: 3-FLUORO-4-IODOANISOLE
• CAS No.: 458-51-5
• Molecular Formula: C7H6FIO
• Molecular Weight: 252.027
• Mol file: 458-51-5.mol

Synonyms:3-FLUORO-4-IODOANISOLE

Chemical Property of 3-FLUORO-4-IODOANISOLE

Chemical Property:

• Vapor Pressure: 0.146mmHg at 25°C
• Boiling Point: 223.1°C at 760 mmHg
• Flash Point: 88.7°C
• PSA: 9.23000
• Density: 1.803g/cm³
• LogP: 2.43890

Purity/Quality:

98%Min ^*data from raw suppliers

2-Fluoro-1-iodo-4-methoxy-benzene ＞97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-FLUORO-4-IODOANISOLE

There total 3 articles about 3-FLUORO-4-IODOANISOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-fluoro-4-(methoxy)aniline (458-52-6) → 2-fluoro-1-iodo-4-methoxybenzene (458-51-5)

Guidance literature:

With hydrogen iodide; sodium iodide; sodium nitrite; In water; at 20 - 90 ℃; for 1h;

Reference yield:

2,4-difluoro-1-iodobenzene (2265-93-2) + potassium methanolate (865-33-8) → 1-iodo-2,4-dimethoxybenzene (20469-63-0) + 2-fluoro-1-iodo-4-methoxybenzene (458-51-5) + 4-fluoro-1-iodo-2-methoxybenzene (450-90-8)

Guidance literature:

With potassium tert-butylate; In 1,4-dioxane; at 45 ℃; for 48h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.03.204

Reference yield:

2-fluoro-4-methoxy-1-nitro-benzene (446-38-8) → 2-fluoro-1-iodo-4-methoxybenzene (458-51-5)

Guidance literature:

Multi-step reaction with 2 steps

1: iron-powder; aqueous acetic acid

2: Diazotization

With iron; acetic acid;

upstream raw materials:

2-fluoro-4-(methoxy)aniline

2-fluoro-4-methoxy-1-nitro-benzene

2,4-difluoro-1-iodobenzene

potassium methanolate

Downstream raw materials:

((2R,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol

methyl 2-((2S,3S,4R)-4-acetoxy-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-3-methylpyrrolidin2-yl)acetate

methyl 2-((2S,3S,4R)-1-(2-fluoro-4-hydroxyphenyl)-4-hydroxy-3-methylpyrrolidin-2-yl)acetate

methyl 2-((2S,3S,4R)-4-acetoxy-1-(2-fluoro-4-hydroxyphenyl)-3-methylpyrrolidin-2-yl)acetate

Refernces

• 1、 -. "PYRROLIDINE GPR40 MODULATORS". Paragraph 00447. . Retrieved 2014/06/11.