Tris(dimethylamino)methane

Base Information

• Chemical Name: Tris(dimethylamino)methane
• CAS No.: 5762-56-1
• Molecular Formula: C7H19 N3
• Molecular Weight: 145.248
• Hs Code.: 2921290000
• European Community (EC) Number: 227-284-0
• UNII: 8T74D2Q5VH
• DSSTox Substance ID: DTXSID20206284
• Nikkaji Number: J209.013I
• Wikipedia: Tris(dimethylamino)methane
• Wikidata: Q28504294
• ChEMBL ID: CHEMBL3301703
• Mol file: 5762-56-1.mol

Synonyms:Tris(dimethylamino)methane;5762-56-1;N,N,N',N',N'',N''-Hexamethylmethanetriamine;[bis(dimethylamino)methyl]dimethylamine;Methanetriamine, N,N,N',N',N'',N''-hexamethyl-;N,N,N,N,N,n-Hexamethylmethanetriamine;8T74D2Q5VH;EINECS 227-284-0;N,N,N',N',N",N"-hexamethylmethanetriamine;trisdimethylaminomethane;tris-dimethylaminomethane;tris (dimethylamino)methane;tris(dimethylamino) methane;tris(dimethylamino)-methane;tris-(dimethylamino)methane;CH(NMe2)3;UNII-8T74D2Q5VH;SCHEMBL868297;Tris(N,N-dimethylamino)methane;CHEMBL3301703;MUMVIYLVHVCYGI-UHFFFAOYSA-;N,N,N',N',N;DTXSID20206284;Tris(dimethylamino)methane, 97%;MFCD00008322;AKOS028108520;bis(dimethylamino)-methyl-dimethyl-amine;AS-46997;N,N,N,N,N,n-Hexamethylmethanetriamine #;FT-0635840;T1057;F11164;Methanetriamine,N,N,N',N',N'',N''-hexamethyl-

Chemical Property of Tris(dimethylamino)methane

Chemical Property:

• Vapor Pressure: 5.24mmHg at 25°C
• Refractive Index: n20/D 1.436(lit.)
• Boiling Point: 143.8°Cat760mmHg
• PKA: 6.50±0.38(Predicted)
• Flash Point: 28.2°C
• PSA: 9.72000
• Density: 0.873g/cm³
• LogP: -0.04520
• Storage Temp.: 2-8°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 145.157897619
• Heavy Atom Count: 10
• Complexity: 69.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

N,N,N'',N'',N'''',N''''-Hexamethylmethanetriamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,C
• Hazard Codes: F,C
• Statements: 11-34
• Safety Statements: 16-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C(N(C)C)N(C)C
• Uses: Reagent for the introduction of the dimethylaminoethylidene group.1 General review;2 RO polymerization of lactide.3 N,N,N'',N'',N'''',N''''-Hexamethylmethanetriamine, can be used in the synthesis of the phosphoramidite derivative of the new nucleoside analog. It can also be used as reagent for the introduction of the dimethylaminoethylidene group. Tris(dimethylamino)methane was used:to prepare the phosphoramidite derivative of the new nucleoside analogas reagent for the introduction of the dimethylaminoethylidene group in ring-opening (RO) polymerization of lactide

Technology Process of Tris(dimethylamino)methane

There total 20 articles about Tris(dimethylamino)methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

butylidenetriphenylphosphorane (3728-50-5) + N,N,N',N'-Tetramethylformamidinium chloride (1071-38-1) → tris(dimethylamino)methane (5762-56-1) + butyltriphenylphosphonium chloride (13371-17-0) + <2-(Dimethylamino)-1-propylvinyl>triphenylphosphonium-chlorid (90601-14-2)

Guidance literature:

In tetrahydrofuran; benzene; for 20h;

Reference yield: 90.0%

propylidenetriphenylphosphorane (16666-78-7) + N,N,N',N'-Tetramethylformamidinium chloride (1071-38-1) → tris(dimethylamino)methane (5762-56-1) + n-propyltriphenylphosphonium chloride (16721-43-0) + <2-(Dimethylamino)-1-ethylvinyl>triphenylphosphonium-chlorid (90601-13-1)

Guidance literature:

In tetrahydrofuran; benzene; for 20h;

Reference yield: 90.0%

N,N,N',N'-Tetramethylformamidinium chloride (1071-38-1) + Triphenyl<(propylthio)methylen>phosphoran (90601-05-1) → tris(dimethylamino)methane (5762-56-1) + triphenyl-propylsulfanylmethyl-phosphonium; chloride (55064-94-3) + <2-(Dimethylamino)-1-(propylthio)vinyl>triphenylphosphonium-chlorid (90601-15-3)

Guidance literature:

In tetrahydrofuran; benzene; for 720h;

upstream raw materials:

Bis(dimethylamino)acetonitrile

lithium dimethylamide

N,N,N',N'-tetramethylformamidinium methyl sulfate

N,N,N',N'-Tetramethylformamidinium chloride

Downstream raw materials:

2-(2-dimethylamino-6-nitrophenyl)acetaldehyde semicarbazone

5-Bromo-1-ethyl-2-[3-(3-fluoro-phenyl)-isoxazol-4-ylmethyl]-1H-benzoimidazole

(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

(R)-5-biphenyl-4-ylmethyl-3-[1-dimethylaminometh-(E/Z)-ylidene]-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

Refernces

• 1、 Kantlehner, Willi,Speh, Peter,Braeuner, Hans J.. "Eine einfache Synthese fuer Trismethane". . p. 905 - 906. Retrieved 1983.
• 2、 Suzuki, Naoyuki,Hofstra, Julie L.,Poremba, Kelsey E.,Reisman, Sarah E.. "Nickel-Catalyzed Enantioselective Cross-Coupling of N-Hydroxyphthalimide Esters with Vinyl Bromides". supporting information. p. 2150 - 2153. Retrieved 2017/04/27.
• 3、 Csihony, Szilard,Beaudette, Tristan T.,Sentman, Alan C.,Nyce, Gregory W.,Waymouth, Robert M.,Hedrick, James L.. "Bredereck's reagent revisited: Latent anionic ring-opening polymerization and transesterification reactions". . p. 1081 - 1086. Retrieved 2007/10/03.