3,5-Dimethylstyrene oxide

Base Information

• Chemical Name: 3,5-Dimethylstyrene oxide
• CAS No.: 80648-26-6
• Molecular Formula: C₁₀H₁₂O
• Molecular Weight: 148.205
• Mol file: 80648-26-6.mol

Synonyms:3,5-Dimethylstyrene 7,8-oxide;3,5-Dimethylstyrene oxide;

Chemical Property of 3,5-Dimethylstyrene oxide

Chemical Property:

• Vapor Pressure: 0.0857mmHg at 25°C
• Melting Point: -59.27°C (estimate)
• Refractive Index: 1.5356
• Boiling Point: 233.3°C at 760 mmHg
• Flash Point: 90.4°C
• PSA: 12.53000
• Density: 1.05g/cm³
• LogP: 2.37470

Purity/Quality:

99%min ^*data from raw suppliers

2-(3,5-DIMETHYLPHENYL)OXIRANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Dimethylstyrene oxide

There total 2 articles about 3,5-Dimethylstyrene oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dimethylbenzaldehyde (5779-95-3) + trimethylsulphonium iodide (2181-42-2) → 2-(3,5-dimethylphenyl)oxirane (702667-14-9,80648-26-6)

Guidance literature:

With water; potassium hydroxide; In acetonitrile; at 60 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ja111700e

Reference yield:

5-bromo-1,3-xylene (556-96-7) → 2-(3,5-dimethylphenyl)oxirane (702667-14-9,80648-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C

1.2: 1.33 h / -78 - 20 °C / Inert atmosphere

2.1: water; potassium hydroxide / acetonitrile / 4 h / 60 °C / Inert atmosphere

With n-butyllithium; water; potassium hydroxide; In tetrahydrofuran; hexane; acetonitrile;

DOI:10.1021/ja111700e

Reference yield: 66.0%

2-(3,5-dimethylphenyl)oxirane (702667-14-9,80648-26-6) + silver(I) trifluoromethanethiolate (811-68-7) → (1-(3,5-dimethylphenyl)ethane-1,2-diyl)bis((trifluoromethyl)sulfane)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium iodide; In toluene; at 85 ℃; for 11h; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201901836

upstream raw materials:

5-bromo-1,3-xylene

3,5-dimethylbenzaldehyde

trimethylsulphonium iodide

Downstream raw materials:

2-azido-2-(3,5-dimethylphenyl)ethanol

2-amino-2-(3,5-dimethylphenyl)ethanol

4-(3,5-dimethylphenyl)-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole

Refernces