2,6-bis[N,N'-(2-acetamidophenyl)carbamoyl]pyridine

Base Information

• Chemical Name: 2,6-bis[N,N'-(2-acetamidophenyl)carbamoyl]pyridine
• CAS No.: 443960-49-4
• Molecular Formula: C₂₃H₂₁N₅O₄
• Molecular Weight: 431.451
• Mol file: 443960-49-4.mol

Synonyms:2,6-bis[N,N'-(2-acetamidophenyl)carbamoyl]pyridine

Chemical Property of 2,6-bis[N,N'-(2-acetamidophenyl)carbamoyl]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2,6-bis[N,N'-(2-acetamidophenyl)carbamoyl]pyridine

There total 2 articles about 2,6-bis[N,N'-(2-acetamidophenyl)carbamoyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2,6-Pyridinedicarbonyl dichloride (3739-94-4) + N-(2-aminophenyl)acetamide (34801-09-7) → 2,6-bis[N,N'-(2-acetamidophenyl)carbamoyl]pyridine (443960-49-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at -50 ℃; for 2h;

DOI:10.1039/b107166c

Reference yield:

1,2-diamino-benzene (95-54-5) → 2,6-bis[N,N'-(2-acetamidophenyl)carbamoyl]pyridine (443960-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / CH₂Cl₂ / 2 h / 0 °C

2: 77 percent / Et₃N / tetrahydrofuran / 2 h / -50 °C

With triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1039/b107166c

Reference yield: 80.0%

tetraethylammonium chloride (56-34-8) + copper dichloride + 2,6-bis[N,N'-(2-acetamidophenyl)carbamoyl]pyridine (443960-49-4) → 2(C2H5)4N(1+)*Cu(NC5H3(CONC6H4NHCOCH3)2)Cl(1-)*Cl(1-)=((C2H5)4N)2(Cu(C23H19N5O4)Cl2)

Guidance literature:

With KH; In N,N-dimethyl-formamide; byproducts: KCl; under Ar; soln. of ligand in DMF treated with solid KH (2 equiv.); solidCuCl2 (1 equiv.) added; stirred for 2 h; filtered; Et4NCl (2 equiv.) ad ded to filtrate; stirred for 2 h; filtered; filtrate concd. under reduced pressure; dissolved in MeCN; crystd. by slow diffusion of Et2O; elem. anal.;

upstream raw materials:

2,6-Pyridinedicarbonyl dichloride

N-(2-aminophenyl)acetamide

1,2-diamino-benzene

Refernces