4-Iodoimidazole

Base Information

• Chemical Name: 4-Iodoimidazole
• CAS No.: 71759-89-2
• Molecular Formula: C3H3IN2
• Molecular Weight: 193.975
• Hs Code.: 2933290090
• Mol file: 71759-89-2.mol

Synonyms:5-Iodo-1H-imidazole;4(5)-Iodo-1(H)-Imidazole;1H-Imidazole,4-iodo- (9CI);4(5)-Iodoimidazole;4-Iodo-1H-imidazole;

Chemical Property of 4-Iodoimidazole

Chemical Property:

• Appearance/Colour: White Solid
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 137-138 °C
• Refractive Index: 1.688
• Boiling Point: 348.468 °C at 760 mmHg
• PKA: 11.46±0.10(Predicted)
• Flash Point: 164.548 °C
• PSA: 28.68000
• Density: 2.336 g/cm³
• LogP: 1.01430
• Storage Temp.: -20°C Freezer
• Sensitive.: Light Sensitive
• Solubility.: Methanol (Slightly)

Purity/Quality:

98.0% ^*data from raw suppliers

4(5)-Iodoimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 26-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: suzuki reaction

Technology Process of 4-Iodoimidazole

There total 8 articles about 4-Iodoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,4,5-triiodoimidazole (1746-25-4) → 5-iodo-1H-imidazole (71759-89-2)

Guidance literature:

With sodium sulfite; In ethanol; water; for 24h; Heating;

DOI:10.1139/v01-092

Reference yield: 96.0%

4,5-diiodo-1H-imidazole (15813-09-9) → 4-iodoimidazole (71759-89-2)

Guidance literature:

With potassium sulfite; In ethanol; water; for 24h; Reagent/catalyst; Reflux;

DOI:10.1002/ejoc.201500520

Reference yield: 81.0%

1H-imidazole (288-32-4) → 4-iodoimidazole (71759-89-2)

Guidance literature:

With 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione; sulfuric acid;

DOI:10.1002/ejoc.201500520

upstream raw materials:

4,5-diiodo-1H-imidazole

2,4,5-triiodoimidazole

1H-imidazole

4-iodo-1H-imidazolium chloride

Downstream raw materials:

4-iodo-1-methyl-1H-imidazole

5-iodo-1N-methyl imidazole

1-benzenesulfonyl-4-iodoimidazole

1-benzyl-5-iodo-1H-imidazole

Refernces

• 1、 Zou, Yi,Wang, Fang,Wang, Yan,Sun, Qirui,Hu, Yue,Li, Yuezhen,Liu, Wen,Guo, Wenjie,Huang, Zhangjian,Zhang, Yihua,Xu, Qiang,Lai, Yisheng. "Discovery of imidazoleisoindole derivatives as potent IDO1 inhibitors: Design, synthesis, biological evaluation and computational studies". . p. 293 - 304. Retrieved 2017/10/05.
• 2、 -. "Preparation method of 4-halogen-1H-imidazole". Paragraph 0031; 0034. . Retrieved 2017/08/28.