Technology Process of (1R,2S)-2-(benzhydrylamino)-3-fluoro-1-(4-(methylsulfonyl)phenyl)propan-1-ol
There total 6 articles about (1R,2S)-2-(benzhydrylamino)-3-fluoro-1-(4-(methylsulfonyl)phenyl)propan-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2S,3S)-1-benzhydryl-2-(fluoromethyl)-3-(4-(methylsulfonyl)phenyl)aziridine;
With
water; toluene-4-sulfonic acid;
In
acetonitrile;
at 40 ℃;
for 24h;
Inert atmosphere;
With
sodium hydrogencarbonate;
In
dichloromethane; water;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1016/j.tet.2011.09.052
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: ethanol / 3 h / Inert atmosphere; Reflux
2.1: (2R)-(+)-3,3'-diphenyl-[2,2'-dinaphthalene]-1,1'-diol; triphenylborane / toluene / 0.17 h / 20 °C / Molecular sieve; Inert atmosphere
2.2: 19 h / -10 - 20 °C / Molecular sieve; Inert atmosphere
3.1: lithium borohydride / tetrahydrofuran / 50 °C / Inert atmosphere
3.2: 1 h / 20 °C / Inert atmosphere
4.1: diethylamino-sulfur trifluoride; triethylamine / dichloromethane / 8 h / -40 - 20 °C / Inert atmosphere
5.1: water; toluene-4-sulfonic acid / acetonitrile / 24 h / 40 °C / Inert atmosphere
5.2: Inert atmosphere
With
lithium borohydride; diethylamino-sulfur trifluoride; (2R)-(+)-3,3'-diphenyl-[2,2'-dinaphthalene]-1,1'-diol; triphenylborane; water; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane; toluene; acetonitrile;
2.1: Wulff aziridination / 2.2: Wulff aziridination / 4.1: Middleton fluorination;
DOI:10.1016/j.tet.2011.09.052
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diethylamino-sulfur trifluoride; triethylamine / dichloromethane / 8 h / -40 - 20 °C / Inert atmosphere
2.1: water; toluene-4-sulfonic acid / acetonitrile / 24 h / 40 °C / Inert atmosphere
2.2: Inert atmosphere
With
diethylamino-sulfur trifluoride; water; toluene-4-sulfonic acid; triethylamine;
In
dichloromethane; acetonitrile;
1.1: Middleton fluorination;
DOI:10.1016/j.tet.2011.09.052
