Technology Process of (2S,3S)-1-benzhydryl-2-(fluoromethyl)-3-(4-(methylsulfonyl)phenyl)aziridine
There total 4 articles about (2S,3S)-1-benzhydryl-2-(fluoromethyl)-3-(4-(methylsulfonyl)phenyl)aziridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diethylamino-sulfur trifluoride; triethylamine;
In
dichloromethane;
at -40 - 20 ℃;
for 8h;
Inert atmosphere;
DOI:10.1016/j.tet.2011.09.052
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: ethanol / 3 h / Inert atmosphere; Reflux
2.1: (2R)-(+)-3,3'-diphenyl-[2,2'-dinaphthalene]-1,1'-diol; triphenylborane / toluene / 0.17 h / 20 °C / Molecular sieve; Inert atmosphere
2.2: 19 h / -10 - 20 °C / Molecular sieve; Inert atmosphere
3.1: lithium borohydride / tetrahydrofuran / 50 °C / Inert atmosphere
3.2: 1 h / 20 °C / Inert atmosphere
4.1: diethylamino-sulfur trifluoride; triethylamine / dichloromethane / 8 h / -40 - 20 °C / Inert atmosphere
With
lithium borohydride; diethylamino-sulfur trifluoride; (2R)-(+)-3,3'-diphenyl-[2,2'-dinaphthalene]-1,1'-diol; triphenylborane; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane; toluene;
2.1: Wulff aziridination / 2.2: Wulff aziridination / 4.1: Middleton fluorination;
DOI:10.1016/j.tet.2011.09.052
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: (2R)-(+)-3,3'-diphenyl-[2,2'-dinaphthalene]-1,1'-diol; triphenylborane / toluene / 0.17 h / 20 °C / Molecular sieve; Inert atmosphere
1.2: 19 h / -10 - 20 °C / Molecular sieve; Inert atmosphere
2.1: lithium borohydride / tetrahydrofuran / 50 °C / Inert atmosphere
2.2: 1 h / 20 °C / Inert atmosphere
3.1: diethylamino-sulfur trifluoride; triethylamine / dichloromethane / 8 h / -40 - 20 °C / Inert atmosphere
With
lithium borohydride; diethylamino-sulfur trifluoride; (2R)-(+)-3,3'-diphenyl-[2,2'-dinaphthalene]-1,1'-diol; triphenylborane; triethylamine;
In
tetrahydrofuran; dichloromethane; toluene;
1.1: Wulff aziridination / 1.2: Wulff aziridination / 3.1: Middleton fluorination;
DOI:10.1016/j.tet.2011.09.052
