(4R)-(+)-T-BUTYLDIMETHYLSILOXY-2-CYCLOPENTEN-1-ONE

Base Information Edit

Chemical Name:(4R)-(+)-T-BUTYLDIMETHYLSILOXY-2-CYCLOPENTEN-1-ONE
CAS No.:61305-35-9
Molecular Formula:C11H20O2Si
Molecular Weight:212.364
Hs Code.:2931900090
Mol file:61305-35-9.mol

Synonyms:2-Cyclopenten-1-one,4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (R)-;(4R)-(+)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-cyclopenten-1-one;(4R)-4-((tert-Butyldimethylsilyl)oxy)-2-cyclopenten-1-one;(R)-(+)-4-[(tert-Butyldimethylsilyl)oxy]-2-cyclopentenone;(R)-(+)-4-tert-Butyldimethylsilyloxy-2-cyclopenten-1-one;(R)-4-(tert-Butyldimethylsilyloxy)-2-cyclopenten-1-one;R)-4-(tert-Butyldimethylsilyloxy)-2-cyclopentenone;

Suppliers and Price of (4R)-(+)-T-BUTYLDIMETHYLSILOXY-2-CYCLOPENTEN-1-ONE

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
(4R)-(+)-T-BUTYLDIMETHYLSILOXY-2-CYCLOPENTEN-1-ONE 95
25g
$ 15166.00

American Custom Chemicals Corporation
(4R)-(+)-T-BUTYLDIMETHYLSILOXY-2-CYCLOPENTEN-1-ONE 95.00%
10G
$ 1732.50

American Custom Chemicals Corporation
(4R)-(+)-T-BUTYLDIMETHYLSILOXY-2-CYCLOPENTEN-1-ONE 95.00%
1G
$ 1576.58

Total 17 raw suppliers

Chemical Property of (4R)-(+)-T-BUTYLDIMETHYLSILOXY-2-CYCLOPENTEN-1-ONE Edit

Chemical Property:

Vapor Pressure:0.0276mmHg at 25°C
Melting Point:26-28 °C
Refractive Index:1.458
Boiling Point:246.1 °C at 760 mmHg
Flash Point:85.4 °C
PSA：26.30000
Density:0.94 g/cm³
LogP:2.90580

Purity/Quality:

99%, ^*data from raw suppliers

(4R)-(+)-T-BUTYLDIMETHYLSILOXY-2-CYCLOPENTEN-1-ONE 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s): R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.;
Hazard Codes: Xn:Harmful;
Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.;
Safety Statements: S36/37:Wear suitable protective clothing and gloves.;

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (4R)-(+)-T-BUTYLDIMETHYLSILOXY-2-CYCLOPENTEN-1-ONE

There total 14 articles about (4R)-(+)-T-BUTYLDIMETHYLSILOXY-2-CYCLOPENTEN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 61305-35-9,61305-36-0,61740-33-8,56745-67-6
4-[(tert-butyldimethylsilyl)oxy]cyclopent-2-enone

: 98-80-6
phenylboronic acid

: 56745-67-6,61305-35-9,61740-33-8,61305-36-0
(4S)-4-tert-butyldimethylsilyloxycyclopent-2-en-1-one

: C₁₇H₂₆O₂Si

Guidance literature:: 4-[(tert-butyldimethylsilyl)oxy]cyclopent-2-enone; With chlorobis(ethylene)rhodium(I) dimer; C₃₇H₃₃O₃P; cesium fluoride; In 1,4-dioxane; water; at 20 ℃; for 0.25h; Schlenk technique; Inert atmosphere;

phenylboronic acid; In 1,4-dioxane; water; at 20 ℃; for 2h; stereoselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1002/adsc.201400459

Reference yield: 52.0%

: 61305-35-9,61305-36-0,61740-33-8,56745-67-6
4-[(tert-butyldimethylsilyl)oxy]cyclopent-2-enone

: 98-80-6
phenylboronic acid

: 61305-35-9
(R)-4-((tert-butyldimethylsilyl)oxy)cyclopent-2-enone

: C₁₇H₂₆O₂Si

Guidance literature:: 4-[(tert-butyldimethylsilyl)oxy]cyclopent-2-enone; With chlorobis(ethylene)rhodium(I) dimer; 1,5-anhydro-4-O-diphenylphosphino-2,3,6-trideoxy-L-threo-hex-2-enitol; triethylamine; cesium fluoride; In 1,4-dioxane; water; at 20 ℃; for 0.25h; Schlenk technique; Inert atmosphere;

phenylboronic acid; In 1,4-dioxane; water; at 20 ℃; for 2h; Overall yield = 113 mg; stereoselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1002/adsc.201400459

Reference yield: 44.0%

: 1391630-27-5
(+/-)-4-oxocyclopenten-2-enyl 2-phenylacetate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1391630-29-7
(R)-4-oxocyclopenten-2-enyl 2-phenylacetate

: 56745-67-6,61305-35-9,61740-33-8,61305-36-0
(4S)-4-tert-butyldimethylsilyloxycyclopent-2-en-1-one

Guidance literature:: (+/-)-4-oxocyclopenten-2-enyl 2-phenylacetate; In di-isopropyl ether; for 72h; pH=7.5; aq. phosphate buffer; Enzymatic reaction;

tert-butyldimethylsilyl chloride; With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; optical yield given as %ee; enantioselective reaction; Cooling with ice;
DOI:10.1016/j.tetasy.2012.05.018