C₂₅H₃₀ClN₇O₄S

Base Information

• Chemical Name: C₂₅H₃₀ClN₇O₄S
• CAS No.: 1353623-58-1
• Molecular Formula: C₂₅H₃₀ClN₇O₄S
• Molecular Weight: 560.077
• Mol file: 1353623-58-1.mol

Synonyms:C₂₅H₃₀ClN₇O₄S

Chemical Property of C₂₅H₃₀ClN₇O₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₃₀ClN₇O₄S

There total 7 articles about C₂₅H₃₀ClN₇O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

azetidine (503-29-7) + 1,3-oxazolidine (504-76-7) + (S)-N-(4-chloro-2-(2-(5,7-dichloropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide (1353628-61-1) → C25H30ClN7O4S (1353623-58-1)

Guidance literature:

1,3-oxazolidine; (S)-N-(4-chloro-2-(2-(5,7-dichloropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 70 ℃; for 2h;

azetidine; In tetrahydrofuran; at 70 ℃; for 2h;

Reference yield:

tert-butyl (2S)-2-{[methoxy(methyl)amino]-carbonyl}piperidine-1-carboxylate (203056-27-3) → C25H30ClN7O4S (1353623-58-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.42 h / -78 - -20 °C / Inert atmosphere

1.2: 3.08 h / -78 - -45 °C

1.3: -78 - 20 °C

2.1: hydrazinium monoacetate / ethanol / 16 h / 20 °C

3.1: sodium methylate / methanol / 5 h / 78 °C

4.1: trichlorophosphate / 3 h / 100 °C

5.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C

5.2: 0.67 h / 20 °C / Cooling with ice

6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 70 °C

6.2: 2 h / 70 °C

With oxalyl dichloride; sodium bis(trimethylsilyl)amide; sodium methylate; hydrazinium monoacetate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

(S)-1-tert-butyl 2-methyl piperidine-1,2-dicarboxylate (200184-53-8) → C25H30ClN7O4S (1353623-58-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran; hexanes / -78 - -40 °C

1.2: -78 - -40 °C

1.3: -78 - 20 °C

2.1: hydrazinium monoacetate / ethanol / 16 h / 20 °C

3.1: sodium methylate / methanol / 5 h / 78 °C

4.1: trichlorophosphate / 3 h / 100 °C

5.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C

5.2: 0.67 h / 20 °C / Cooling with ice

6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 70 °C

6.2: 2 h / 70 °C

With oxalyl dichloride; sodium bis(trimethylsilyl)amide; sodium methylate; hydrazinium monoacetate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; hexanes; ethanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

azetidine

1,3-oxazolidine

(S)-N-(4-chloro-2-(2-(5,7-dichloropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

tert-butyl (2S)-2-{[methoxy(methyl)amino]-carbonyl}piperidine-1-carboxylate

Refernces