C₂₈H₄₉IN₄

Base Information

• Chemical Name: C₂₈H₄₉IN₄
• CAS No.: 1268872-77-0
• Molecular Formula: C₂₈H₄₉IN₄
• Molecular Weight: 568.628
• Mol file: 1268872-77-0.mol

Synonyms:C₂₈H₄₉IN₄

Chemical Property of C₂₈H₄₉IN₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₄₉IN₄

There total 3 articles about C₂₈H₄₉IN₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-iodoisophthalaldehyde (777854-97-4) + (3R,4R)-3,4-diamino-2,2,5,5-tetramethylhexane (171357-23-6) → C28H49IN4 (1268872-77-0)

Guidance literature:

In toluene; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tetasy.2010.12.002

Reference yield:

benzene-1,3-dicarbonitrile (626-17-5) → C28H49IN4 (1268872-77-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; 2-methyltetrahydrofuran; n-heptane; ethylbenzene / 0.25 h / -90 °C / Inert atmosphere

1.2: -90 - 20 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 0 °C / Inert atmosphere

2.2: 40 °C / Inert atmosphere

2.3: 0.25 h / Cooling with ice; Inert atmosphere

3.1: toluene / 3 h / 0 - 20 °C / Inert atmosphere

With diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; 2-methyltetrahydrofuran; n-heptane; dichloromethane; ethylbenzene; toluene;

DOI:10.1016/j.tetasy.2010.12.002

Reference yield:

2-iodo-1,3-benzenedicarbonitrile (81725-16-8) → C28H49IN4 (1268872-77-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 0 °C / Inert atmosphere

1.2: 40 °C / Inert atmosphere

1.3: 0.25 h / Cooling with ice; Inert atmosphere

2.1: toluene / 3 h / 0 - 20 °C / Inert atmosphere

With diisobutylaluminium hydride; In dichloromethane; toluene;

DOI:10.1016/j.tetasy.2010.12.002

upstream raw materials:

benzene-1,3-dicarbonitrile

2-iodoisophthalaldehyde

(3R,4R)-3,4-diamino-2,2,5,5-tetramethylhexane

2-iodo-1,3-benzenedicarbonitrile

Downstream raw materials:

2,6-di[(4R,5R)-4,5-di-tert-butyl-4,5-dihydro-1H-imidazol-2-yl]iodobenzene

Refernces