Technology Process of (R)-N-methyl-N-(piperidin-3-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
There total 3 articles about (R)-N-methyl-N-(piperidin-3-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium cyanoborohydride; acetic acid / methanol / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / -30 °C / Inert atmosphere; Reflux
2.2: Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 60 °C
4.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Inert atmosphere; Reflux
With
lithium aluminium tetrahydride; ammonium formate; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / -30 °C / Inert atmosphere; Reflux
1.2: Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 60 °C
3.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Inert atmosphere; Reflux
With
lithium aluminium tetrahydride; ammonium formate; N-ethyl-N,N-diisopropylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 60 °C
2: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Inert atmosphere; Reflux
With
ammonium formate; N-ethyl-N,N-diisopropylamine;
palladium 10% on activated carbon;
In
methanol; N,N-dimethyl-formamide;