2-(2-NITROPHENYL)ETHANAMINE

Base Information

• Chemical Name: 2-(2-NITROPHENYL)ETHANAMINE
• CAS No.: 33100-15-1
• Molecular Formula: C8H10 N2 O2
• Molecular Weight: 166.18
• Hs Code.: 2921499090
• Mol file: 33100-15-1.mol

Synonyms:Phenethylamine,o-nitro- (6CI,8CI); 2-(2-Aminoethyl)nitrobenzene; b-(o-Nitrophenyl)ethylamine

Chemical Property of 2-(2-NITROPHENYL)ETHANAMINE

Chemical Property:

• Boiling Point: 147 °C(Press: 13 Torr)
• PKA: 9.37±0.10(Predicted)
• PSA: 71.84000
• Density: 1.206±0.06 g/cm3(Predicted)
• LogP: 2.31950

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Nitrophenethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Nitrophenethylamine can be used as CGRP receptor antagonists.

Technology Process of 2-(2-NITROPHENYL)ETHANAMINE

There total 18 articles about 2-(2-NITROPHENYL)ETHANAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-nitro-benzeneacetonitrile (610-66-2) → 2-(2-aminoethyl)nitrobenzene (33100-15-1)

Guidance literature:

2-nitro-benzeneacetonitrile; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 ℃; for 8h; Heating / reflux;

With methanol; for 1h; Heating / reflux;

Reference yield:

2-nitrophenethyl azide (33100-26-4) → 2-(2-aminoethyl)nitrobenzene (33100-15-1)

Guidance literature:

2-nitrophenethyl azide; With triphenylphosphine; calcium carbonate; In benzene; at 20 ℃;

With hydrogen bromide; In water; acetic acid; at 100 ℃; for 1h;

Reference yield:

(2-bromoethyl)-2-nitrobenzene (16793-89-8) → 2-(2-aminoethyl)nitrobenzene (33100-15-1)

Guidance literature:

Multistep reaction; (i) aq. NaN₃, DMSO, (ii) Ph₃P, benzene, (iii) aq. HBr, AcOH;

DOI:10.1139/v71-329

upstream raw materials:

3-(2-nitrophenyl)propionic acid

N-(2-nitro-phenethyl)-acetamide

phenethylamine

(2-bromoethyl)-2-nitrobenzene

Downstream raw materials:

[2-(2-nitrophenyl)ethyl]carbamic acid tert-butyl ester

N-2-(2-Nitrophenyl)aethylsarcosin

N-Benzolsulfonyl-N-2-(2-nitrophenyl)-ethylglycin

Ethyl-N-methyl-N-2-(2-nitrophenyl)-ethyl-β-alanat

Refernces

• 1、 Wei, Linyi,Gao, Xiaoqi,Warne, Robert,Hao, Xueshi,Bussiere, Dirksen,Gu, Xiang-Ju,Uno, Tetsuo,Liu, Yi. "Design and synthesis of benzoazepin-2-one analogs as allosteric binders targeting the PIF pocket of PDK1". scheme or table. p. 3897 - 3902. Retrieved 2010/09/03.
• 2、 -. "CGRP receptor antagonists". Page/Page column 139. . Retrieved 2008/06/13.