2-DI-TERT-BUTYLPHOSPHINO-3,4,5,6-TETRAM&

Base Information

• Chemical Name: 2-DI-TERT-BUTYLPHOSPHINO-3,4,5,6-TETRAM&
• CAS No.: 857356-94-6
• Molecular Formula: C₃₃H₅₃P
• Molecular Weight: 480.758
• Mol file: 857356-94-6.mol

Synonyms:2-Di-tert-butylphosphino-3,4,5,6'-triisopropyl-1,1'-biphenyl;Bis(2-methyl-2-propanyl)(2',4',6'-triisopropyl-3,4,5,6-tetramethyl-2-biphenylyl)phosphine;

Chemical Property of 2-DI-TERT-BUTYLPHOSPHINO-3,4,5,6-TETRAM&

Chemical Property:

• Melting Point: 168-172 °C
• Boiling Point: 534.094 °C at 760 mmHg
• Flash Point: 294.365 °C
• PSA: 13.59000
• LogP: 10.66160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2-Di-t-butylphosphino-3,4,5,6-tetramethyl-2',4',6'-tri-i-propyl)-1,1'-biphenyl, min. 98% Me4 t-BuXPhos ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37-60

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ligand used in a palladium-catalyzed amidation of aryl chlorides.

Technology Process of 2-DI-TERT-BUTYLPHOSPHINO-3,4,5,6-TETRAM&

There total 2 articles about 2-DI-TERT-BUTYLPHOSPHINO-3,4,5,6-TETRAM& which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

di(tert-butyl)chlorophosphine (13716-10-4) + 2,4,6-triisopropyl-1-bromobenzene (21524-34-5) + 1,2-dibromo-3,4,5,6-tetramethylbenzene (36321-73-0) → 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl (857356-94-6)

Guidance literature:

2,4,6-triisopropyl-1-bromobenzene; With magnesium; ethylene dibromide; In tetrahydrofuran; at 60 ℃; for 0.25h;

1,2-dibromo-3,4,5,6-tetramethylbenzene; In tetrahydrofuran; at 60 ℃; for 1.5h;

di(tert-butyl)chlorophosphine; With copper(l) iodide; In tetrahydrofuran; at 75 ℃; for 40h;

DOI:10.1021/ja050471r

Reference yield:

1,2,3,4-Tetramethylbenzene (488-23-3) → 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl (857356-94-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 85 percent / bromine; ZnCl₂ / acetic acid / 14 h / 20 °C

2.1: magnesium; 1,2-dibromoethane / tetrahydrofuran / 1.5 h / 60 °C

2.2: tetrahydrofuran / 1.5 h / 60 °C

2.3: 62 percent / CuCl / tetrahydrofuran / 40 h / 75 °C

With bromine; magnesium; ethylene dibromide; zinc(II) chloride; In tetrahydrofuran; acetic acid;

DOI:10.1002/anie.200601253

Reference yield: 99.0%

2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl (857356-94-6) + (tetrahydrothiophene)gold(I) chloride (39929-21-0) → chloro[(2’,4’,6’-triisopropyl-3,4,5,6-tetramethyl-1,1’-biphenyl-2-yl)di-tert-butylphosphine]gold(I) (1140907-91-0)

Guidance literature:

In dichloromethane; for 1.75h;

DOI:10.1071/CH13552

upstream raw materials:

di(tert-butyl)chlorophosphine

2,4,6-triisopropyl-1-bromobenzene

1,2-dibromo-3,4,5,6-tetramethylbenzene

1,2,3,4-Tetramethylbenzene

Downstream raw materials:

chloro[(2’,4’,6’-triisopropyl-3,4,5,6-tetramethyl-1,1’-biphenyl-2-yl)di-tert-butylphosphine]gold(I)

Refernces

• 1、 Vorogushin, Andrei V.,Huang, Xiaohua,Buchwald, Stephen L.. "Use of tunable ligands allows for intermolecular Pd-catalyzed C-O bond formation". . p. 8146 - 8149. Retrieved 2007/10/03.