2-AMINO-3-(TRIFLUOROMETHYL)BENZOIC ACID

Base Information

• Chemical Name: 2-AMINO-3-(TRIFLUOROMETHYL)BENZOIC ACID
• CAS No.: 313-12-2
• Molecular Formula: C8H6F3NO2
• Molecular Weight: 205.136
• Hs Code.: 29224999
• Mol file: 313-12-2.mol

Synonyms:m-Toluicacid, 2-amino-a,a,a-trifluoro- (6CI,8CI);2-Amino-3-(trifluoromethyl)benzoic acid;3-(a,a,a-Trifluoromethyl)anthranilicacid;3-Trifluoromethylanthranilic acid;

Chemical Property of 2-AMINO-3-(TRIFLUOROMETHYL)BENZOIC ACID

Chemical Property:

• Vapor Pressure: 0.00052mmHg at 25°C
• Melting Point: 157-160 °C(lit.)
• Refractive Index: 1.533
• Boiling Point: 296.9 °C at 760 mmHg
• PKA: 4.51±0.10(Predicted)
• Flash Point: 133.3 °C
• PSA: 63.32000
• Density: 1.489 g/cm³
• LogP: 2.56700
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-3-(trifluoromethyl)benzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: A useful intermediate for the syntheses of antimicrobial benzoisothiazolones and dithiobis(benzamides).

Technology Process of 2-AMINO-3-(TRIFLUOROMETHYL)BENZOIC ACID

There total 6 articles about 2-AMINO-3-(TRIFLUOROMETHYL)BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(trifluoromethyl)benzenamine (88-17-5) → 2-amino-3-(trifluoromethyl)benzoic acid (313-12-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium sulfate / water / 40 °C

1.2: 8 h / Reflux

2.1: sulfuric acid / 60 - 80 °C

3.1: sodium hydroxide; dihydrogen peroxide / water

With sulfuric acid; dihydrogen peroxide; sodium sulfate; sodium hydroxide; In water;

DOI:10.1016/j.cclet.2017.01.019

Reference yield:

(E)-2-(hydroxyimino)-N-(2-(trifluoromethyl)phenyl)acetamide (444-93-9) → 2-amino-3-(trifluoromethyl)benzoic acid (313-12-2)

Guidance literature:

Multi-step reaction with 2 steps

1: conc. H₂SO₄ / 60 - 80 °C

2: 5percent aq. NaOH, 30percent H₂O₂ / 0.5 h / 50 °C

With sodium hydroxide; sulfuric acid; dihydrogen peroxide;

DOI:10.1016/0223-5234(94)90132-5

Reference yield:

2-hydroxyimino-N-(2-trifluoromethyl-phenyl)-acetamide (444-93-9) → 2-amino-3-(trifluoromethyl)benzoic acid (313-12-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 60 - 80 °C

2: sodium hydroxide; dihydrogen peroxide / water

With sulfuric acid; dihydrogen peroxide; sodium hydroxide; In water;

DOI:10.1016/j.cclet.2017.01.019

upstream raw materials:

2-nitro-3-(trifluoromethyl)aniline

methanol

7-trifluoromethylisatin

(E)-2-(hydroxyimino)-N-(2-(trifluoromethyl)phenyl)acetamide

Downstream raw materials:

2-amino-N-(2-chlorophenyl)-3-trifluoromethylbenzamide

3-(trifluoromethyl)benzoic acid

methyl 2-amino-3-trifluoromethyl-benzoate

4-(trifluoromethyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

Refernces

• 1、 Wu, Chang-Chun,Wang, Bao-Lei,Liu, Jing-Bo,Wei, Wei,Li, Yu-Xin,Liu, Yang,Chen, Ming-Gui,Xiong, Li-Xia,Yang, Na,Li, Zheng-Ming. "Design, synthesis and insecticidal activities of novel anthranilic diamides containing fluorinated groups as potential ryanodine receptors activitors". . p. 1248 - 1251. Retrieved 2017/06/19.
• 2、 Reissenweber, Gernot,Mangold, Dietrich. "Oxidation von Isatinen zu Anthranilsaeureestern". . p. 914 - 915. Retrieved 2007/10/02.