1-PHENYLPIPERAZINE

Base Information

• Chemical Name: 1-PHENYLPIPERAZINE
• CAS No.: 63921-23-3
• Molecular Formula: C10H14N2
• Molecular Weight: 176.261
• Hs Code.: 2933399090
• Mol file: 63921-23-3.mol

Synonyms:1-Phenylpiperazine;

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Chemical Property of 1-PHENYLPIPERAZINE

Chemical Property:

• Vapor Pressure: 0.00159mmHg at 25°C
• Refractive Index: n20/D 1.588(lit.)
• Boiling Point: 287.2 °C at 760 mmHg
• PKA: 10.28±0.20(Predicted)
• Flash Point: 138.3 °C
• PSA: 15.27000
• Density: 1.028 g/cm³
• LogP: 1.49000
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 22-24-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Phenyl-4-piperidinamine has been discovered to be a HIV-1 reverse transcriptase inhibitor.

Technology Process of 1-PHENYLPIPERAZINE

There total 17 articles about 1-PHENYLPIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

tert-butyl (1-phenylpiperidin-4-yl)carbamate (1185314-73-1) → 1-phenylpiperidin-4-ylamine (63921-23-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield: 78.0%

1-phenyl-piperidin-4-one oxime (7402-94-0) → 1-phenylpiperidin-4-ylamine (63921-23-3)

Guidance literature:

With hydrogen; Raney nickel; In methanol; at 20 ℃; for 6h;

Reference yield: 60.0%

4-aminopiperidine (13035-19-3) + chlorobenzene (108-90-7) → 1-phenylpiperidin-4-ylamine (63921-23-3) + 1-phenyl-4-(phenylamino)piperidine + phenyl-piperidin-4-yl-amine (23056-29-3)

Guidance literature:

With sodium t-butanolate; DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In xylene; at 130 ℃; for 24h;

DOI:10.1021/jo062301i

upstream raw materials:

ethanol

aniline

1-phenyl-piperidin-4-one oxime

4-aminopiperidine

Downstream raw materials:

1-(1-Phenyl-4-piperidyl)-4-<(4-cyano-1-naphthyl)methylene>piperidine

4-[5-Bromo-2-(1-phenyl-piperidin-4-ylamino)-pyrimidin-4-yloxy]-3,5-dimethyl-benzonitrile

Refernces

• 1、 -. "PIPERIDINE DERIVATIVES AS HDAC1/2 INHIBITORS". Page/Page column 61; 62. . Retrieved 2016/06/28.
• 2、 -. "2-OXO-2- (2-PHENYL-5,6,7,8-TETRAHYDRO-INDOLIZIN-3-YL) -ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ANTIFUNGAL AGENTS". Page/Page column 19. . Retrieved 2011/02/15.