N-Phenylpiperidin-4-amine

Base Information

• Chemical Name: N-Phenylpiperidin-4-amine
• CAS No.: 23056-29-3
• Molecular Formula: C11H16 N2
• Molecular Weight: 176.261
• Hs Code.: 2933399090
• European Community (EC) Number: 245-402-9
• NSC Number: 80678
• UNII: CQ9ROS690X
• DSSTox Substance ID: DTXSID40177624
• Nikkaji Number: J307.766G
• Wikidata: Q27275649
• Mol file: 23056-29-3.mol

Synonyms:N-Phenylpiperidin-4-amine;23056-29-3;4-anilinopiperidine;4-Piperidinamine, N-phenyl-;4-(phenylamino)piperidine;N-Phenyl-4-piperidinamine;phenylpiperidin-4-yl-amine;CQ9ROS690X;Phenyl-piperidin-4-yl-amine;n-phenyl-n-(4-piperidyl)amine;NSC-80678;UNII-CQ9ROS690X;Phenyl-Piperidine-4-YL-Amine;n-Phenyl-4-piperidinamine;NSC80678;EINECS 245-402-9;PHENYL-PIPERIDINE-4-YL-AMINE;Despropionyl norfentanyl;Piperidine, 4-anilino-;Phenylpiperidin-4-ylamine;N-Phenylpiperidin-4-aMin;SCHEMBL918020;AMY5286;DTXSID40177624;N-(PIPERIDIN-4-YL)ANILINE;CCG-40376;N-Phenyl-N-(4-piperidinyl)amine #;NSC 80678;STK500906;AKOS004120341;AC-25621;DS-14563;FENTANYL IMPURITY I {EP IMPURITY];BB 0254752;CS-0069837;EN300-57317;A847441;FENTANYL CITRATE IMPURITY F [EP IMPURITY];W-201962;Q27275649

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of N-Phenylpiperidin-4-amine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Boiling Point: 312°Cat760mmHg
• PKA: 9.83±0.10(Predicted)
• Flash Point: 185.3°C
• PSA: 24.06000
• Density: 1.052g/cm³
• LogP: 2.25230
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 176.131348519
• Heavy Atom Count: 13
• Complexity: 135

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1NC2=CC=CC=C2

Technology Process of N-Phenylpiperidin-4-amine

There total 11 articles about N-Phenylpiperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(tert-butoxycarbonyl)-4-phenylaminopiperidine (125541-22-2) → phenyl-piperidin-4-yl-amine (23056-29-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 92.0%

N-(1-ethoxycarbonyl-4-piperidinyl)aniline (116512-92-6) → phenyl-piperidin-4-yl-amine (23056-29-3)

Guidance literature:

With hydrogenchloride; In water; for 16h; Heating;

Reference yield: 60.0%

4-aminopiperidine (13035-19-3) + chlorobenzene (108-90-7) → 1-phenylpiperidin-4-ylamine (63921-23-3) + 1-phenyl-4-(phenylamino)piperidine + phenyl-piperidin-4-yl-amine (23056-29-3)

Guidance literature:

With sodium t-butanolate; DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In xylene; at 130 ℃; for 24h;

DOI:10.1021/jo062301i

upstream raw materials:

N-(1-ethoxycarbonyl-4-piperidinyl)aniline

4-aminopiperidine

bromobenzene

chlorobenzene

Downstream raw materials:

(1-Phenethyl-piperidin-4-yl)-phenyl-amine

1-phenyl-2-(4-phenylamino-piperidin-1-yl)-ethanol

C₁₈H₂₁N₃S

Refernces

• 1、 -. "Pyrimidyl piperazine urea TRPV1 antagonistic/MOR agonistic double-target compound as well as preparation method and application thereof". Paragraph 0060; 0064. . Retrieved 2021/08/28.
• 2、 Jevti?, Ivana I.,Penji?evi?, Jelena Z.,Ivanovi?, Milovan D.,Kosti?-Raja?i?, Sla?ana V.. "Synthetic route towards potential bivalent ligands possessing opioid and D2/D3 pharmacophores". . p. 639 - 647. Retrieved 2019/08/30.