This is a common method where an amine and a ketone or aldehyde are reacted in the presence of a reducing agent. The amine serves as the 1-position substituent, and the ketone/aldehyde provides the 4-position substituent.
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N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(1-methylpiperidin-4-yl)acetamide
9
3
C13H17NO4S
hydrogen peroxide
Sodium bicarbonate
5-(3,5-dimethyl-1H-pyrazol-1-yl)-2-phenyl-1,3-oxazole-4-carbothioamide
TPP-3
(S)-methyl 2-phenyl-2-(piperdin-1-yl)propanoate
8-methoxy-7-methoxymethoxy-3-methyl-5-phenyl-1,3,4,5-tetrahydro-benzo[d]azepin-2-one
methyl (2S,5E)-8-methyl-4-oxo-2-(tritylamino)non-5-enoate
(2R,6R)-2,6-dimethylpiperidine hydrochloride
(5-OXO-5-PHENYL-PENTYL)-CARBAMIC ACID TERT-BUTYL ESTER
N-(2-bromobenzyl)-4-methybenzenesulfonamide
(S)-4-((R)-4-Benzyloxycarbonylamino-4-methoxycarbonyl-butyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester
6-benzenesulfonylamino-1-benzyl-4-methylhexahydro-1H-1,4-diazepine
Ethanone, 1-[1,4,5,6-tetrahydro-1-(1-methylethyl)-2-pyridinyl]- (9CI)
(αS,1'S)-N-(1-Phenylethyl)-2-fluoro-α-methylphenylmethylamine
[3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propylamino]-acetic acid methyl ester
N-(4-(dimethylamino)phenyl)picolinamide
N-phenyl-9-aminononanol acetate ester
N,N-bis(3-phenylpropyl)aniline
methyl 6-hydroxy-2-oxo-6-cyclohexene-1-carboxylate
Phenol, 2,2',2''-[nitrilotris(methylene)]tris[6-methyl-
4-methoxy-N-(2,4,6-trimethylbenzyl)aniline
