129422-96-4

Basic information

• Product Name: 1H-1,4,7-Triazonine, octahydro-1-[(4-methylphenyl)sulfonyl]-
• CAS NO: 129422-96-4
• Molecular Formula: C13H21N3O2S
• Molecular Weight: 283.395
• Mol File: 129422-96-4.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1H-1,4,7-Triazonine, octahydro-1-[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,4,7-Triazonine, octahydro-1-[(4-methylphenyl)sulfonyl]-(129422-96-4)
• EPA Substance Registry System: 1H-1,4,7-Triazonine, octahydro-1-[(4-methylphenyl)sulfonyl]-(129422-96-4)

Safety Data

• Hazardous Substances Data: 129422-96-4(Hazardous Substances Data)

Usage

Explanation

The compound consists of 11 carbon atoms, 17 hydrogen atoms, 3 nitrogen atoms, 2 oxygen atoms, and 1 sulfur atom.
2. Organic heterocyclic compound

Explanation

It contains a ring structure with different elements (heteroatoms) such as nitrogen and sulfur in its molecular structure.
3. Sulfonyl derivative

Explanation

It has a sulfonyl group (-SO2-) attached to a 1H-1,4,7-triazonine ring, which contributes to its diverse biological activities.
4. Potential applications in pharmaceutical and agrochemical industries

Explanation

Due to its various biological activities, this compound can be used in the development of new drugs and agrochemicals.

Explanation

The compound has been shown to possess these properties, making it a potential therapeutic agent for various medical conditions.
6. Building block in organic synthesis and medicinal chemistry

Explanation

It can be used as a starting material or intermediate in the synthesis of novel drug candidates and agrochemicals.
7. Promising biological activities

Explanation

Studies have demonstrated that this compound exhibits potential for further development as a therapeutic agent due to its positive biological effects.

Biological activities

anticonvulsant, anti-inflammatory, and analgesic properties

Upstream product

• 16695-22-0 N,N-bis(tosyloxyethyl)-p-toluenesulfonamide 
• 107-15-3 ethylenediamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 56187-04-3 1,4,7-tritosyl-1,4,7-triazaheptane 
• 52667-89-7 N,N',N-tris(p-toluenesulfonyl)-1,4,7-triazacyclononane 
• 6315-52-2 1,2-bis-tosyloxyethane 
• 134209-57-7 N,N''-bis(diethoxyphosphoryl)-N'-tosyldiethylenetriamine 

Downstream Products

• 266346-04-7 1,4-bis-(3-nitro-benzyl)-7-(toluene-4-sulfonyl)-[1,4,7]triazonane 
• 188116-51-0 1,4-dimethyl-7-tosyl-1,4,7-triazacyclononane 
• 1383561-98-5 1,4-bis(2-mercaptoethyl)-7-(p-toluenesulfonyl)-1,4,7-triazacyclononane 
• 95388-08-2 N,N'-bis(p-toluenesulfonyl)-1,4,7-triazacyclononane 
• 1092370-25-6 C₂₅H₄₁N₃O₆S 
• 1022983-26-1 1-(p-toluenesulfonyl)-4,7-di(picolyl)-1,4,7-triazacyclononane 
• 226917-74-4 4,10-bis-(toluene-4-sulfonyl)-1,4,7,10-tetraaza-bicyclo[5.5.2]tetradecane 
• 266346-06-9 [4,7-bis-(3-nitro-benzyl)-[1,4,7]triazonan-1-yl]-acetic acid butyl ester 
• 266346-08-1 [4,7-bis-(3-amino-benzyl)-[1,4,7]triazonan-1-yl]-acetic acid butyl ester 
• 266346-07-0 [4,7-bis-(3-nitro-benzyl)-[1,4,7]triazonan-1-yl]-acetic acid 
• 266346-05-8 1,4-bis-(3-nitro-benzyl)-[1,4,7]triazonane 
• 168324-42-3 C₃₁H₄₃N₅O₆S₃ 
• 226917-73-3 4,10-bis-(toluene-4-sulfonyl)-1,4,7,10-tetraaza-bicyclo[5.5.2]tetradecane-2,6-dione 
• 176483-80-0 1,4-diisopropyl-7-(p-tolylsulfonyl)-1,4,7-triazacyclononane 

Relevant articles and documents

DNA hydrolysis catalyzed by tris(diisopropyl-1,4,7-triazacyclononanes) ethane metal complexes

Novel trinuclear coordinated ligands were designed using three of 1,4,7-triazacyclononane moieties with a tribromo linker. These ligands show greater capability and potency in association with various metal ions. Tris(diisopropyl-1,4,7-triazacyclononanes)ethane (2) associated with Cu 2+ and Ce4+ ions shows better reactivity to achieve DNA hydrolysis at 37 °C at pH 8 for 5 hr. Using high resolution of polyacrylamide gel electrophoresis, DNA cleavage reaction in Tris-HCl buffer causes a nicking site at the single-stranded region. Alternatively, the reaction in HEPES buffer shows a random DNA cleavage included the double-stranded region. Hydrolysis of phosphodiester bond mediated by trinuclear metal complex is capable of performing at the physiological temperature 37 °C, but it has a lower reactivity compared to mono- and di-nuclear metal complexes. The result suggests that trinuclear metal complexes have a bulky environment to prevent from going toward the phosphodiester bond. The design of an efficient chemical hydrolyase will be a challenge in order to construct a coordinate ligand with the enhancement of hydrolytic activity and the reduction of the steric environment.

Acceleration of hydrolytic DNA cleavage by dicopper(II) complexes with p-cresol-derived dinucleating ligands at slightly acidic pH and mechanistic insights

Four dicopper(II) complexes, [Cu2(ˉ-X)(bcmp)](ClO4)2 [X = OH (1a) and X = Cl (1b)], [Cu2(ˉ-OH)(Me4bcmp)]-(ClO4)2 (2), and [Cu2(bcc)](ClO4)3 (3),

An improved synthesis of 1,4,7-triazacyclononanes (tacns) and 1,4,7,10-tetraazacyclododecanes (cyclens)

Reaction of tosylbis[2-(tosyloxy)ethyl]amine with ethylenediamine gives 1-tosyl-1,4,7-triazacyclononane in good yield. A similar reaction of tosylbis[2-(tosyloxy)ethyl]amine with diethylenetriamine gives 1-tosyl-1,4,7,10-tetraazacyclododecane. These tosyl