137996-01-1

Basic information

• Product Name: XJ 445
• CAS NO: 137996-01-1
• Molecular Weight: 221.275
• Mol File: 137996-01-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: XJ 445(CAS DataBase Reference)
• NIST Chemistry Reference: XJ 445(137996-01-1)
• EPA Substance Registry System: XJ 445(137996-01-1)

Safety Data

• Hazardous Substances Data: 137996-01-1(Hazardous Substances Data)

Upstream product

• 145021-97-2 1-<(tert-butyloxy)carbonyl>-4-(2-(4-fluorophenyl)-2-oxoethyl)piperidine 
• 78056-63-0 2-(1-acetyl-4-piperidinyl)-1-(4-fluorophenyl)ethanone 
• 462-06-6 fluorobenzene 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 40110-55-2 ethyl 2-(1-benzylpiperidine-4-ylidene)acetate 
• 71879-59-9 ethyl (1-benzylpiperidin-4-yl)acetate 
• 78056-60-7 (1-acetylpiperidin-4-yl)acetic acid 
• 78056-61-8 2-(1-Acetyl-4-piperidyl)acetyl chloride 
• 78056-59-4 ethyl 2-(1-acetyl-4-piperidyl)acetate 
• 108-89-4 picoline 
• 6576-05-2 1-(4-fluorophenyl)-2-(4-pyridyl)ethanone 
• 451-46-7 4-fluorobenzoic acid ethyl ester 

Downstream Products

• 137995-66-5 1-(4-fluorophenyl)-2-<1-(phenylmethyl)piperidin-4-yl>-1-ethanone 
• 145021-97-2 1-<(tert-butyloxy)carbonyl>-4-(2-(4-fluorophenyl)-2-oxoethyl)piperidine 
• 639468-66-9 4-[2-(4-fluorophenyl)-2-hydroxyethyl]piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Syntheses and Binding Studies of New [(Aryl)(aryloxy)methyl]piperidine Derivatives and Related Compounds as Potential Antidepressant Drugs with High Affinity for Serotonin (5-HT) and Norepinephrine (NE) Transporters

In a wide search program toward new, efficient, and fast-acting antidepressant drugs, we have prepared series of new compounds having an (aryl)(aryloxy)methyl moiety linked directly or through a methylene chain to different substituted and unsubstituted cycles (isoquinoline, piperazine, piperidine, tetrahydropyran, or cyclopentane). These compounds have been evaluated for their affinities for serotonin (5-HT) transporter (SERT) and 5-HT1A and 5-HT2A receptors. Racemic mixtures of 4-[(aryl)(aryloxy)methyl]piperidine derivatives showed much higher affinity values for SERT than fluoxetine and resulted in lack of affinity for 5-HT 1A and 5-HT2A receptors. Some of these racemic mixtures were resolved to their enantiomers and tested for binding to norepinephrine (NE) transporter (NET), dopamine (DA) transporter (DAT), and α2 receptor. Several of these enantiomers [(-)-15b, (-)-15j, (-)-15t, (+)-15u] displayed a dual binding profile with affinities for SERT and NET with K i i = 1.9 and 13.5 nM, respectively), and further pharmacological characterization is in progress for its evaluation as a antidepressant.