639468-66-9

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-[2-(4-fluorophenyl)-2-hydroxyethyl]-, 1,1-dimethylethyl ester
• CAS NO: 639468-66-9
• Molecular Formula: C18H26FNO3
• Molecular Weight: 323.408
• Mol File: 639468-66-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-[2-(4-fluorophenyl)-2-hydroxyethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-[2-(4-fluorophenyl)-2-hydroxyethyl]-, 1,1-dimethylethyl ester(639468-66-9)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-[2-(4-fluorophenyl)-2-hydroxyethyl]-, 1,1-dimethylethyl ester(639468-66-9)

Safety Data

• Hazardous Substances Data: 639468-66-9(Hazardous Substances Data)

Usage

Molecular Structure

The compound features a piperidine ring, a carboxylic acid group, a 4-(2-(4-fluorophenyl)-2-hydroxyethyl) substituent, and a 1,1-dimethylethyl ester functional group.

Usage

It is commonly used in organic synthesis and pharmaceutical research as a building block for the development of pharmacologically active compounds.

Biological Activity

The structure of the compound suggests potential biological activity, making it a promising candidate for further research and development.

Precursor in Drug Synthesis

The compound may be used as a precursor for the synthesis of drugs or therapeutic agents, potentially leading to the discovery of new medications.

Medical Applications

Due to its potential biological activity and pharmacological properties, the compound may have applications in the treatment of various medical conditions, although further research is needed to confirm its efficacy and safety.

Upstream product

• 78056-59-4 ethyl 2-(1-acetyl-4-piperidyl)acetate 
• 137996-01-1 4-<2-(4-fluorophenyl)-2-oxoethyl>piperidine 
• 78056-63-0 2-(1-acetyl-4-piperidinyl)-1-(4-fluorophenyl)ethanone 
• 78056-61-8 2-(1-Acetyl-4-piperidyl)acetyl chloride 
• 78056-60-7 (1-acetylpiperidin-4-yl)acetic acid 
• 71879-59-9 ethyl (1-benzylpiperidin-4-yl)acetate 
• 40110-55-2 ethyl 2-(1-benzylpiperidine-4-ylidene)acetate 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 462-06-6 fluorobenzene 
• 145021-97-2 1-<(tert-butyloxy)carbonyl>-4-(2-(4-fluorophenyl)-2-oxoethyl)piperidine 

Relevant articles and documents

Syntheses and Binding Studies of New [(Aryl)(aryloxy)methyl]piperidine Derivatives and Related Compounds as Potential Antidepressant Drugs with High Affinity for Serotonin (5-HT) and Norepinephrine (NE) Transporters

In a wide search program toward new, efficient, and fast-acting antidepressant drugs, we have prepared series of new compounds having an (aryl)(aryloxy)methyl moiety linked directly or through a methylene chain to different substituted and unsubstituted cycles (isoquinoline, piperazine, piperidine, tetrahydropyran, or cyclopentane). These compounds have been evaluated for their affinities for serotonin (5-HT) transporter (SERT) and 5-HT1A and 5-HT2A receptors. Racemic mixtures of 4-[(aryl)(aryloxy)methyl]piperidine derivatives showed much higher affinity values for SERT than fluoxetine and resulted in lack of affinity for 5-HT 1A and 5-HT2A receptors. Some of these racemic mixtures were resolved to their enantiomers and tested for binding to norepinephrine (NE) transporter (NET), dopamine (DA) transporter (DAT), and α2 receptor. Several of these enantiomers [(-)-15b, (-)-15j, (-)-15t, (+)-15u] displayed a dual binding profile with affinities for SERT and NET with K i i = 1.9 and 13.5 nM, respectively), and further pharmacological characterization is in progress for its evaluation as a antidepressant.