78056-63-0

Basic information

• Product Name: 2-(1-acetyl-4-piperidinyl)-1-(4-fluorophenyl)ethanone
• Synonyms: 2-(1-acetyl-4-piperidinyl)-1-(4-fluorophenyl)ethanone
• CAS NO: 78056-63-0
• Molecular Weight: 263.312
• Mol File: 78056-63-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(1-acetyl-4-piperidinyl)-1-(4-fluorophenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-acetyl-4-piperidinyl)-1-(4-fluorophenyl)ethanone(78056-63-0)
• EPA Substance Registry System: 2-(1-acetyl-4-piperidinyl)-1-(4-fluorophenyl)ethanone(78056-63-0)

Safety Data

• Hazardous Substances Data: 78056-63-0(Hazardous Substances Data)

Upstream product

• 462-06-6 fluorobenzene 
• 78056-61-8 2-(1-Acetyl-4-piperidyl)acetyl chloride 
• 73415-84-6 2-(piperidin-4-yl)acetic acid hydrochloride 
• 6622-91-9 2-(pyridine-4-yl)acetic acid hydrochloride 
• 78056-59-4 ethyl 2-(1-acetyl-4-piperidyl)acetate 
• 78056-60-7 (1-acetylpiperidin-4-yl)acetic acid 
• 71879-59-9 ethyl (1-benzylpiperidin-4-yl)acetate 
• 40110-55-2 ethyl 2-(1-benzylpiperidine-4-ylidene)acetate 
• 3612-20-2 1-phenylmethyl-4-piperidone 

Downstream Products

• 131416-70-1 1-acetyl-4-(4-dimethylaminobenzoylmethyl)piperidine 
• 131416-72-3 1-acetyl-4-(4-piperidinobenzoylmethyl)piperidine 
• 639468-66-9 4-[2-(4-fluorophenyl)-2-hydroxyethyl]piperidine-1-carboxylic acid tert-butyl ester 
• 145021-97-2 1-<(tert-butyloxy)carbonyl>-4-(2-(4-fluorophenyl)-2-oxoethyl)piperidine 
• 137996-01-1 4-<2-(4-fluorophenyl)-2-oxoethyl>piperidine 

Relevant articles and documents

Syntheses and Binding Studies of New [(Aryl)(aryloxy)methyl]piperidine Derivatives and Related Compounds as Potential Antidepressant Drugs with High Affinity for Serotonin (5-HT) and Norepinephrine (NE) Transporters

In a wide search program toward new, efficient, and fast-acting antidepressant drugs, we have prepared series of new compounds having an (aryl)(aryloxy)methyl moiety linked directly or through a methylene chain to different substituted and unsubstituted cycles (isoquinoline, piperazine, piperidine, tetrahydropyran, or cyclopentane). These compounds have been evaluated for their affinities for serotonin (5-HT) transporter (SERT) and 5-HT1A and 5-HT2A receptors. Racemic mixtures of 4-[(aryl)(aryloxy)methyl]piperidine derivatives showed much higher affinity values for SERT than fluoxetine and resulted in lack of affinity for 5-HT 1A and 5-HT2A receptors. Some of these racemic mixtures were resolved to their enantiomers and tested for binding to norepinephrine (NE) transporter (NET), dopamine (DA) transporter (DAT), and α2 receptor. Several of these enantiomers [(-)-15b, (-)-15j, (-)-15t, (+)-15u] displayed a dual binding profile with affinities for SERT and NET with K i i = 1.9 and 13.5 nM, respectively), and further pharmacological characterization is in progress for its evaluation as a antidepressant.

CYCLIC AMINE COMPOUNDS AND THEIR USE

There is provided a cyclic amine compound of the formula. wherein B means a saturated or unsaturated 5- to 7-membered aza-heterocyclic group which may be substituted; A means a bond or an alkylene or alkenylene group which may be substituted by hydrocarbon residues, oxo, hydroxyimino, and/or hydroxy, means either a single bond or a double bond (provided that when A means a bond, means a single bond); R2 and R3 independently mean a hydrogen atom or a hydrocarbon residue which may be substituted (provided that both of R2 and R3 are not hydrogen atoms) or jointly form a cyclic amino group together with the adjacent nitrogen atom, n is 0, 1 or 2 and p is 1 or 2 or a physiologically acceptable salt thereof. The compounds are useful for therapy of cerebral edema, acute symptoms in cerebral apoplexy and protection of brain and nerve cell, or useful as anticholinesterase or as brain function-improving agent.