78056-60-7

Basic information

• Product Name: N-Acetylpiperidine-4-acetic acid
• Synonyms: (N-Acetylpiperidin-4-yl)acetic acid;1-Acetyl-4-piperidineacetic acid;N-Acetylpiperidine-4-acetic acid;4-Piperidineacetic acid, 1-acetyl-
• CAS NO: 78056-60-7
• Molecular Formula: C₉H₁₅NO₃
• Molecular Weight: 185.2203
• Mol File: 78056-60-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 389.6 °C at 760 mmHg
• Flash Point: 189.4 °C
• Appearance: /
• Density: 1.150
• CAS DataBase Reference: N-Acetylpiperidine-4-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-Acetylpiperidine-4-acetic acid(78056-60-7)
• EPA Substance Registry System: N-Acetylpiperidine-4-acetic acid(78056-60-7)

Safety Data

• Hazardous Substances Data: 78056-60-7(Hazardous Substances Data)

Usage

General Description

N-Acetylpiperidine-4-acetic acid is a chemical compound that consists of a piperidine ring with an N-acetyl group at the 4-position and an acetic acid group attached to the piperidine ring. It is a derivative of piperidine and is used as a building block in the synthesis of various pharmaceutical and agrochemical compounds. N-Acetylpiperidine-4-acetic acid has the potential for anti-inflammatory and analgesic properties, and has been studied for its use in the treatment of pain and inflammation. N-Acetylpiperidine-4-acetic acid is also used in the production of certain drugs and other organic compounds due to its versatile reactivity and functional groups.

InChI:InChI=1S/C9H15NO3/c1-7(11)10-4-2-8(3-5-10)6-9(12)13/h8H,2-6H2,1H3,(H,12,13)

Upstream product

• 51052-78-9 4-piperidinylacetic acid 
• 6622-91-9 2-(pyridine-4-yl)acetic acid hydrochloride 
• 71879-59-9 ethyl (1-benzylpiperidin-4-yl)acetate 
• 40110-55-2 ethyl 2-(1-benzylpiperidine-4-ylidene)acetate 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 78056-59-4 ethyl 2-(1-acetyl-4-piperidyl)acetate 
• 108-24-7 acetic anhydride 
• 73415-84-6 2-(piperidin-4-yl)acetic acid hydrochloride 

Downstream Products

• 1422444-94-7 C₁₅H₁₇F₂NO₂ 
• 639468-66-9 4-[2-(4-fluorophenyl)-2-hydroxyethyl]piperidine-1-carboxylic acid tert-butyl ester 
• 639468-64-7 4-(2-hydroxy-2-phenylethyl)piperidine-1-carboxylic acid tert-butyl ester 
• 137996-01-1 4-<2-(4-fluorophenyl)-2-oxoethyl>piperidine 
• 145021-97-2 1-<(tert-butyloxy)carbonyl>-4-(2-(4-fluorophenyl)-2-oxoethyl)piperidine 
• 78056-63-0 2-(1-acetyl-4-piperidinyl)-1-(4-fluorophenyl)ethanone 
• 6719-96-6 1-phenyl-2-(piperidin-4-yl)ethanone 

Relevant articles and documents

Syntheses and Binding Studies of New [(Aryl)(aryloxy)methyl]piperidine Derivatives and Related Compounds as Potential Antidepressant Drugs with High Affinity for Serotonin (5-HT) and Norepinephrine (NE) Transporters

In a wide search program toward new, efficient, and fast-acting antidepressant drugs, we have prepared series of new compounds having an (aryl)(aryloxy)methyl moiety linked directly or through a methylene chain to different substituted and unsubstituted cycles (isoquinoline, piperazine, piperidine, tetrahydropyran, or cyclopentane). These compounds have been evaluated for their affinities for serotonin (5-HT) transporter (SERT) and 5-HT1A and 5-HT2A receptors. Racemic mixtures of 4-[(aryl)(aryloxy)methyl]piperidine derivatives showed much higher affinity values for SERT than fluoxetine and resulted in lack of affinity for 5-HT 1A and 5-HT2A receptors. Some of these racemic mixtures were resolved to their enantiomers and tested for binding to norepinephrine (NE) transporter (NET), dopamine (DA) transporter (DAT), and α2 receptor. Several of these enantiomers [(-)-15b, (-)-15j, (-)-15t, (+)-15u] displayed a dual binding profile with affinities for SERT and NET with K i i = 1.9 and 13.5 nM, respectively), and further pharmacological characterization is in progress for its evaluation as a antidepressant.

Carbonyl piperazinyl and piperidinyl compounds

Novel carbonyl piperazinyl and piperidinyl compounds and pharmaceutical compositions are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel carbonyl piperazinyl or piperidinyl compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.

Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1.0: STR1 to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds of formulas 5.0, 5.1 and 5.2, wherein R is --C(R20)(R21)(R46), and 5.3, 5.3A and 5.3B, wherein R is --N(R25)(R48), are disclosed. Also disclosed are processes for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3. Further disclosed are novel compounds which are intermediates in the process for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3.