1512-30-7 Usage
Description
Difluoromethanesulphonyl chloride, also known as methanesulfonyl difluoride, is an organic compound with the chemical formula (CH3)2SO2Cl2. It is a colorless to pale yellow liquid that is highly reactive and soluble in organic solvents. difluoromethanesulphonyl chloride is known for its ability to act as a sulfonylating and fluorinating agent in various chemical reactions.
Uses
1. Used in Pharmaceutical Industry:
Difluoromethanesulphonyl chloride is used as a reactant for the synthesis of ketoconazole sulfonamide analogs, which are antifungal agents. Its role in this application is to facilitate the formation of the desired chemical structure, contributing to the development of effective treatments for fungal infections.
2. Used in Organic Synthesis:
Difluoromethanesulphonyl chloride is employed as a sulfonylating agent in the synthesis of various organic compounds. Its reactivity allows it to react with a wide range of substrates, making it a versatile tool in the creation of new molecules with potential applications in various fields.
3. Used in Fluorination Reactions:
In the field of fluorochemistry, difluoromethanesulphonyl chloride serves as a fluorinating agent. It can be used to introduce fluorine atoms into organic molecules, which can significantly alter their properties, such as reactivity, stability, and biological activity. This makes it a valuable reagent in the development of new compounds with improved characteristics.
4. Used in Research and Development:
Difluoromethanesulphonyl chloride is also utilized in research and development settings, where it can be employed to explore new chemical reactions and investigate the properties of various organic compounds. Its unique reactivity and versatility make it an important tool for scientists working in the fields of organic chemistry, medicinal chemistry, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 1512-30-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,5,1 and 2 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1512-30:
(6*1)+(5*5)+(4*1)+(3*2)+(2*3)+(1*0)=47
47 % 10 = 7
So 1512-30-7 is a valid CAS Registry Number.
InChI:InChI=1/CHClF2O2S/c2-7(5,6)1(3)4/h1H
1512-30-7Relevant articles and documents
Photoredox-Catalyzed Intramolecular Difluoromethylation of N-Benzylacrylamides Coupled with a Dearomatizing Spirocyclization: Access to CF2H-Containing 2-Azaspiro[4.5]deca-6,9-diene-3,8-diones
Zhang, Zuxiao,Tang, Xiao-Jun,Dolbier, William R.
, p. 1048 - 1051 (2016)
A visible light-mediated difluoromethylation of N-benzylacrylamides with HCF2SO2Cl as the HCF2 radical precursor is described. The reaction incorporates a tandem cyclization/dearomatization process to afford various difluoromethylated 2-azaspiro[4.5]deca-6,9-diene-3,8-diones bearing adjacent quaternary stereocenters under mild conditions in moderate to excellent yields.
Photoredox-Catalyzed Tandem Insertion/Cyclization Reactions of Difluoromethyl and 1,1-Difluoroalkyl Radicals with Biphenyl Isocyanides
Zhang, Zuxiao,Tang, Xiaojun,Dolbier, William R.
supporting information, p. 4401 - 4403 (2015/09/28)
Using visible-light photoredox conditions, difluoromethylation and 1,1-difluoroalkylation of biphenyl isocyanides have allowed the synthesis of a series of 6-(difluoromethyl)- and 6-(1,1-difluoroalkyl)phenanthridines via tandem addition/cyclization/oxidation processes. The reactions are carried out in wet dioxane at room temperature using fac-Ir(ppy)3 as catalyst to form a large variety of substituted phenanthridine products in good to excellent yield.
Photoredox-catalyzed tandem radical cyclization of N-arylacrylamides: General methods to construct fluorinated 3,3-disubstituted 2-oxindoles using fluoroalkylsulfonyl chlorides
Tang, Xiao-Jun,Thomoson, Charles S.,Dolbier, William R.
supporting information, p. 4594 - 4597 (2015/01/08)
Fluorinated radicals were generated from RfSO2Cl by photoredox catalysis under mild conditions, where Rf = n-C4F9, CF3, CF2H, CH2F, CH2CF3, and CF2CO2Me. This method provided a general way to construct fluorinated 2-oxindoles from reaction with N-arylacrylamides via a proposed tandem radical cyclization process.