28635-78-1

Basic information

• Product Name: L-Leucine, L-phenylalanyl-, 1,1-dimethylethyl ester
• CAS NO: 28635-78-1
• Molecular Formula: C19H30N2O3
• Molecular Weight: 334.459
• Mol File: 28635-78-1.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: L-Leucine, L-phenylalanyl-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, L-phenylalanyl-, 1,1-dimethylethyl ester(28635-78-1)
• EPA Substance Registry System: L-Leucine, L-phenylalanyl-, 1,1-dimethylethyl ester(28635-78-1)

Safety Data

• Hazardous Substances Data: 28635-78-1(Hazardous Substances Data)

Upstream product

• 3303-55-7 L-Phe-Leu 
• 115-11-7 isobutene 
• 21691-53-2 L-leucine tert-butyl ester 
• 63-91-2 L-phenylalanine 
• 1310361-09-1 N-(2-(triphenylsilyl)ethoxy)carbonyl-L-phenylalanyl-L-leucine tert-butyl ester 
• 122236-89-9 DC-FM-bar-Phe-OH 
• 100167-06-4 TCBOC-Phe-OH 
• 2748-02-9 L-leucine tert-butyl ester hydrochloride 
• 35661-40-6 N-Fmoc L-Phe 
• 1161-13-3 N-Cbz-L-Phe 
• 116864-70-1 Noc-Phe-Leu-OtBu 
• 84891-01-0 Fmoc-Phe-Leu-OtBu 
• 134982-29-9 TCBOC-Phe-Leu-OtBu 
• 29842-94-2 (S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)-4-methylpentanoate 

Downstream Products

• 77426-95-0 Z-Gly-Gly-Phe-Leu-O-t-butyl 
• 138850-03-0 Cbz-Leu-Leu-Phe-Leu-OtBu 
• 149204-99-9 Fmoc-Gly-L-Phe-L-Leu-OtBu 
• 116264-39-2 (S)-2-{(S)-2-[2-(4-Methoxy-benzylsulfanyl)-ethylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid tert-butyl ester 
• 108607-67-6 Boc-L-Tyr(Dmp)-D-Ala-Gly-L-Phe-D-Leu-OBu(t) 
• 101493-43-0 hZ-Gly-Gly-Phe-Leu-O-t-Bu 
• 107941-84-4 N,N-diallyl-O-tert-butyltyrosylglycylglycylphenylalanylleucine tert-butyl ester 
• 107960-00-9 N,N-bis(cyclopropylmethyl)-O-tert-butyltyrosylglycylglycylphenylalanylleucine tert-butyl ester 
• 109335-06-0 N,N-dibenzyl-O-tert-butyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylphenylalanylleucine tert-butyl ester 
• 85574-41-0 Z-Tyr(Z)-(D)Ala-Gly-Phe-Leu-OBu-t 
• 107941-88-8 5>enkephalin trifluoroacetate 
• 107959-99-9 5>enkephalin trifluoroacetate 
• 122269-93-6 DC-FM-bar-Tyr(t-Bu)-Gly-Gly-Phe-Leu-O-t-Bu 
• 77426-99-4 AcOH-Gly-Gly-Phe-Leu-O-t-butyl 

Relevant articles and documents

Peptide Bond Formation of Amino Acids by Transient Masking with Silylating Reagents

A one-pot peptide bond-forming reaction has been developed using unprotected amino acids and peptides. Two different silylating reagents, HSi[OCH(CF3)2]3 and MTBSTFA, are instrumental for the successful implementation of this approach, being used for the activation and transient masking of unprotected amino acids and peptides at C-termini and N-termini, respectively. Furthermore, CsF and imidazole are used as catalysts, activating HSi[OCH(CF3)2]3 and also accelerating chemoselective silylation. This method is versatile as it tolerates side chains that bear a range of functional groups, while providing up to >99% yields of corresponding peptides without any racemization or polymerization.

Stereocontrolled [11C]Alkylation of N-Terminal Glycine Schiff Bases To Obtain Dipeptides

The use of various quaternary ammonium salts as chiral phase-transfer catalysts allowed effective and stereoselective radiochemical [11C]alkylation to obtain functionalized dipeptides. We herein report a broadly applicable procedure for the asymmetric [11C]alkylation of dipeptides to give labeled N-terminal peptides by using different [11C]alkyl halides. Contended stereoselectivities of the reactions were observed by using 11C-labeled alkyl halides, [11C]methyl iodide and [11C]benzyl iodide, and diastereomeric ratios with different specialized catalysts of 95:5 and 90:10 were achieved, respectively. Accordingly, the straightforward synthesis of enantioenriched compounds should play a vital role in peptide-based radiopharmaceutical development and positron emission tomography imaging.

Synthesis of IB-01212 by multiple N-methylations of peptide bonds

There are many natural peptides with multiple N-methylamino acids that exhibit potent attractive biological activities. N-methylation of a peptide bond(s) is also one of the standard approaches in medicinal chemistry of bioactive peptides, to improve the