3303-55-7

Basic information

• Product Name: H-PHE-LEU-OH
• Synonyms: PHE-LEU;H-PHE-LEU-OH;L-PHENYLALANYL-L-LEUCINE;L-PHE-LEU;L-Leucine, L-phenylalanyl-;phenylalanylleucine;L-Phe-L-Leu-OH;Phe-Leu-OH
• CAS NO: 3303-55-7
• Molecular Formula: C₁₅H₂₂N₂O₃
• Molecular Weight: 278.35
• Product Categories: Amino Acid Derivatives
• Mol File: 3303-55-7.mol
• Article Data: 23

Chemical Properties

• Melting Point: 258-260 °C
• Boiling Point: 516.2 °C at 760 mmHg
• Flash Point: 266 °C
• Appearance: White to off white powder
• Density: 1.144 g/cm³
• Vapor Pressure: 1.77E-11mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: -15°C
• PKA: 3.15±0.10(Predicted)
• CAS DataBase Reference: H-PHE-LEU-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-PHE-LEU-OH(3303-55-7)
• EPA Substance Registry System: H-PHE-LEU-OH(3303-55-7)

Safety Data

• Hazardous Substances Data: 3303-55-7(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Definition

ChEBI: A dipeptide obtained by formal condensation of the carboxy group of L-phenylalanine with the amino group of L-leucine.

InChI:InChI=1/C15H22N2O3/c1-10(2)8-13(15(19)20)17-14(18)12(16)9-11-6-4-3-5-7-11/h3-7,10,12-13H,8-9,16H2,1-2H3,(H,17,18)(H,19,20)

Upstream product

• 24733-23-1 Pipoc-Phe-Leu 
• 61-90-5 L-leucine 
• 81917-69-3 N-(1-Benzotriazolylcarbonyl)-L-phenylalanin 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 63649-15-0 L-phenylalanyl-L-leucine benzyl ester 
• 38678-59-0 L-Phe-L-Leu-NH₂ 
• 81678-16-2 leucine enkephalin acetate 
• 63808-83-3 Z(OMe)-Phe-Leu-OH 
• 92466-04-1 Trt-Phe-Leu-OBzl 
• 86938-34-3 N--phenylalanyl-leucin-benzylester 
• 615-28-1 o-phenylenediamine dihydrochloride 
• 4313-73-9 N-[N-[(phenylmethoxy)carbonyl]-L-phenylalanyl]-L-leucine 
• 47672-25-3 N-trityl-L-phenylalanine 
• 1738-69-8 L-Leucine benzyl ester 

Downstream Products

• 76939-20-3 Z(OMe)-Gly-Phe-Leu-OH 
• 109123-78-6 N-(3,4,4-trimethyl-1,2-dioxetan-3-ylmethoxycarbonyl)-L-phenylalanyl-L-leucine 
• 61131-31-5 Boc-Tyr(Bzl)-Gly-Gly-Phe-Leu-OH 
• 15373-56-5 glycyl-L-phenylalanyl-L-leucine 
• 88767-09-3 N-(c-NOPY)-glycyl-L-phenylalanyl-L-leucine 
• 117088-01-4 Z-Glyt-Phe-Leu 
• 76939-18-9 Z-Tyr-D-Arg(Mts)-Gly-Phe-Leu-OH 
• 63-91-2 L-phenylalanine 
• 28635-78-1 L-phenylalanyl-L-leucine tert-butyl ester 
• 80645-37-0 (S)-2-[(S)-2-(2-{2-[(S)-2-Benzyloxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid 
• 38155-45-2 methyl L-phenylalanyl-L-leucinate hydrochloride 
• 3354-31-2 3-(2-methylpropyl)-6-benzyl-2,5-diketopiperazine 
• 67559-10-8 C₂₁H₃₈N₂O₃Si₂ 
• 76939-25-8 H-Tyr-Arg-Gly-Phe-Leu-OH 

Relevant articles and documents

Multifunctional ionic liquid-bound polystyrene resin with high loading capacity as support in solid-phase peptide synthesis

Polystyrene resin-bound ionic liquids (PSILs) with high loading capacities were prepared by immobilizing multifunctional ionic liquids (ILs) on modified polystyrene (PS) resin and used in the solid phase peptide synthesis. Introduction of hydrophobic anio

γ-Valerolactone (GVL): An eco-friendly anchoring solvent for solid-phase peptide synthesis

Due to the hazardous nature of CH2Cl2, regulatory authorities have imposed restrictions to minimize or even stop its use. It has therefore become imperative to identify environmentally benign solvents to replace it. Here we report on a bio derived solvent, γ-valerolactone, for the incorporation of the first amino acid onto p-alkoxybenzyl alcohol resin in solid-phase peptide synthesis. Satisfactory loading values (by a spectrophotometric method) were achieved. Furthermore, racemization and dipeptide formation were also checked and found to be acceptable.

Peptide bond formation by aminolysin-A catalysis: A simple approach to enzymatic synthesis of diverse short oligopeptides and biologically active puromycins

A new S9 family aminopeptidase derived from the actinobacterial thermophile Acidothermus cellulolyticus was cloned and engineered into a transaminopeptidase by site-directed mutagenesis of catalytic Ser491 into Cys. The engineered biocatalyst, designated aminolysin-A, can catalyze the formation of peptide bonds to give linear homo-oligopeptides, hetero-dipeptides, and cyclic dipeptides using cost-effective substrates in a one-pot reaction. Aminolysin-A can recognize several C-terminal-modified amino acids, including the l- and d-forms, as acyl donors as well as free amines, including amino acids and puromycin aminonucleoside, as acyl acceptors. The absence of amino acid esters prevents the formation of peptides; therefore, the reaction mechanism involves aminolysis and not a reverse reaction of hydrolysis. The aminolysin system will be a beneficial tool for the preparation of structurally diverse peptide mimetics by a simple approach.