81678-16-2 Usage
Description
Leucine Enkephalin Acetate Salt, also known as [Leu5]-Enkephalin, is a naturally occurring pentapeptide neurotransmitter derived from the larger peptide Met-Enkephalin. It is composed of five amino acids, including leucine at the fifth position, and plays a crucial role in the modulation of pain perception and the body's response to stress. This peptide is known for its affinity to the delta-opioid receptors, making it a significant molecule in the field of neurobiology and pharmacology.
Uses
Used in Molecular Dynamics Studies:
Leucine Enkephalin Acetate Salt is utilized as a model neurotransmitter in molecular dynamics studies. It aids researchers in understanding the insertion and interaction of neurotransmitters with lipid bilayer membranes, which is vital for comprehending the mechanisms of neuronal signaling and membrane stability.
Used in Pharmaceutical Research:
Leucine Enkephalin Acetate Salt serves as a key component in pharmaceutical research, particularly in the development of pain management therapies and treatments targeting the opioid system. Its interaction with delta-opioid receptors makes it a valuable candidate for the design of drugs with potential applications in pain relief and addiction treatment.
Used in Neurobiology:
In the field of neurobiology, Leucine Enkephalin Acetate Salt is employed to study the mechanisms of pain perception, stress response, and the overall functioning of the nervous system. Understanding the role of this neurotransmitter can lead to advancements in the treatment of neurological disorders and the development of more effective analgesics.
Used in Drug Design and Development:
Leucine Enkephalin Acetate Salt is used as a template in drug design and development, particularly for the creation of peptide-based drugs and therapies. Its structure and function provide insights into the design of molecules that can modulate the opioid system, potentially leading to the development of safer and more effective pain management treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 81678-16-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,6,7 and 8 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 81678-16:
(7*8)+(6*1)+(5*6)+(4*7)+(3*8)+(2*1)+(1*6)=152
152 % 10 = 2
So 81678-16-2 is a valid CAS Registry Number.
81678-16-2Relevant articles and documents
A RAPID NON-ACIDOLYTIC METHOD FOR DEPROTECTION AND REMOVAL OF PEPTIDES FROM SOLID PHASE RESINS - APPLICATIONS OF AMMONIUM FORMATE CATALYTIC TRANSFER HYDROGENATION
Anwer, Mohmed K.,Spatola, Arno F.
, p. 4369 - 4372 (1981)
Ammonium formate aided catalytic transfer hydrogenation has been employed in the cleavage, and concommitant deprotection, of the pentapeptide leucine enkephalin from the Merrifield peptide resin under ambient conditions of temperature and pressure in a neutral medium.
NEW SYNTHESES OF LEU5-ENKEPHALIN AND ITS TYR4-ANALOG
Siemion, Ignacy Z.,Klis, Wieslaw A.,Nawrocka, Eleonora
, p. 2219 - 2222 (2007/10/02)
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