51632-06-5

Basic information

• Product Name: 5-HYDROXYMETHYLINDANE
• Synonyms: 5-HYDROXYMETHYLINDANE;Indan-5-yl-methanol
• CAS NO: 51632-06-5
• Molecular Formula: C₁₀H₁₂O
• Molecular Weight: 148.2
• Product Categories: pharmacetical
• Mol File: 51632-06-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 73.5-74.5 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
• Boiling Point: 277.7°C at 760 mmHg
• Flash Point: 131.2°C
• Appearance: /
• Density: 1.119g/cm³
• Vapor Pressure: 0.00214mmHg at 25°C
• Refractive Index: 1.593
• PKA: 14.50±0.10(Predicted)
• CAS DataBase Reference: 5-HYDROXYMETHYLINDANE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-HYDROXYMETHYLINDANE(51632-06-5)
• EPA Substance Registry System: 5-HYDROXYMETHYLINDANE(51632-06-5)

Safety Data

• Hazardous Substances Data: 51632-06-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H12O/c11-7-8-4-5-9-2-1-3-10(9)6-8/h4-6,11H,1-3,7H2

Upstream product

• 30084-91-4 indan-5-carbaldehyde 
• 113364-54-8 1-(2-indan-5-yl-2-oxo-ethyl)-pyridinium; iodide 
• 65898-38-6 indan-5-carboxylic acid 
• 4228-10-8 1-indan-5-yl-ethanone 
• 496-11-7 INDANE 
• 6134-54-9 5-bromoindane 
• 24425-40-9 indan-5-amine 
• 50-00-0 formaldehyd 
• 2396-63-6 hepta-1,6-diyne 
• 107-19-7 propargyl alcohol 
• 86031-43-8 methyl 5-indanecarboxylate 
• 105640-11-7 Indancarbonsaeure-(5)-ethylester 

Downstream Products

• 501649-52-1 5-(bromomethyl)-2,3-dihydro-1H-indene 
• 51629-71-1 3-Methyl-2-p-tolyl-butyric acid indan-5-ylmethyl ester 
• 13203-56-0 indan-5-ylmethylamine 
• 1187212-05-0 4-(indan-5-ylmethoxy)benzaldehyde 
• 18775-43-4 (5-indanyl)acetonitrile 
• 56635-88-2 3t-(indanyl-⁽⁵⁾)-acrylic acid 
• 65898-38-6 indan-5-carboxylic acid 
• 23291-98-7 3-(2.3-Dihydro-1H-inden-5-yl)-propanoic acid 
• 56635-88-2 3-(5-Indanyl)-prop-2-ensaeure 
• 14927-65-2 3,6,7,8-tetrahydro-2H-as-indacen-1-one 
• 14927-64-1 3,5,6,7-tetrahydro-2H-s-indacen-1-one 
• 495-52-3 s-hydrindacene 
• 30084-91-4 indan-5-carbaldehyde 
• 18775-42-3 5-chloromethylindane 

Relevant articles and documents

Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype

As universal heterodimer partners of many nuclear receptors, the retinoid X receptors (RXRs) constitute key transcription factors. They regulate cell proliferation, differentiation, inflammation, and metabolic homeostasis and have recently been proposed as potential drug targets for neurodegenerative and inflammatory diseases. Owing to the hydrophobic nature of RXR ligand binding sites, available synthetic RXR ligands are lipophilic, and their structural diversity is limited. Here, we disclose the computer-assisted discovery of a novel RXR agonist chemotype and its systematic optimization toward potent RXR modulators. We have developed a nanomolar RXR agonist with high selectivity among nuclear receptors and superior physicochemical properties compared to classical rexinoids that appears suitable for in vivo applications and as lead for future RXR-targeting medicinal chemistry.

Chiral N-phosphino sulfinamide ligands in rhodium(I)-catalyzed [2+2+2] cycloaddition reactions

The combination of cationic rhodium(I) complexes with N-phosphino tert-butylsulfinamides (PNSO) ligands is efficient for catalytic intra- and intermolecular [2+2+2] cycloaddition reactions. PNSO ligands are a new class of chiral bidentate ligands, which h

MODULATORS OF CFTR

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.