61501-04-0

Basic information

• Product Name: 2,2-DIMETHYL-1-PHENYL-PROPYLAMINE
• Synonyms: 2,2-DIMETHYL-1-PHENYL-PROPYLAMINE
• CAS NO: 61501-04-0
• Molecular Formula: C₁₁H₁₇N
• Molecular Weight: 163.26
• Mol File: 61501-04-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 231.2 °C at 760 mmHg
• Flash Point: 96.9 °C
• Appearance: /
• Density: 0.926 g/cm³
• Vapor Pressure: 0.0631mmHg at 25°C
• Refractive Index: 1.515
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.95±0.10(Predicted)
• CAS DataBase Reference: 2,2-DIMETHYL-1-PHENYL-PROPYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIMETHYL-1-PHENYL-PROPYLAMINE(61501-04-0)
• EPA Substance Registry System: 2,2-DIMETHYL-1-PHENYL-PROPYLAMINE(61501-04-0)

Safety Data

• Hazardous Substances Data: 61501-04-0(Hazardous Substances Data)

Usage

General Description

2,2-DIMETHYL-1-PHENYL-PROPYLAMINE, also known as Benzphetamine, is a chemical compound that belongs to the amphetamine class of psychoactive drugs. It is commonly used as an anorectic agent to suppress appetite and aid in weight loss. Benzphetamine works by stimulating the release of norepinephrine and dopamine in the central nervous system, which leads to a decrease in appetite and an increase in metabolism. It is often used in combination with diet and exercise for the treatment of obesity. However, it has the potential for abuse and dependence and is classified as a Schedule III controlled substance in the United States. Common side effects of Benzphetamine include insomnia, dizziness, nervousness, and elevated heart rate.

InChI:InChI=1/C11H17N/c1-11(2,3)10(12)9-7-5-4-6-8-9/h4-8,10H,12H2,1-3H3

Upstream product

• 938-16-9 2,2-dimethylpropiophenone 
• 3835-64-1 2,2-dimethyl-1-phenylpropan-1-ol 
• 6668-41-3 pivalophenone oxime 
• 52777-99-8 N-benzylidene-S-phenylthiohydroxylamine 
• 594-19-4 tert.-butyl lithium 
• 17599-61-0 N-benzylidene-1,1,1-trimethylsilanamine 
• 2259-30-5 tert-butylmagnesium bromide 
• 677-22-5 tert-butylmagnesium chloride 
• 100-47-0 benzonitrile 
• 100-52-7 benzaldehyde 
• 630-19-3 pivalaldehyde 
• 111098-60-3 1-(benzotriazol-1-yl)-1-chloro-2,2-dimethylpropane 
• 42071-02-3 1-Phenyl-1-formylamin-2,2-dimethylpropan 
• 160204-33-1 C₂₉H₃₀NP 

Downstream Products

• 35781-21-6 benzylidene-(2,2-dimethyl-1-phenyl-propyl)-amine 
• 90495-72-0 1-tert-butyl-3-(2,2-dimethyl-1-phenylpropyl)thiourea 
• 71690-15-8 (1R,2S)-2-((R)-2,2-Dimethyl-1-phenyl-propylamino)-1,2-diphenyl-ethanol 
• 71690-15-8 (1S,2R)-2-((R)-2,2-Dimethyl-1-phenyl-propylamino)-1,2-diphenyl-ethanol 
• 133175-29-8 (R)-N-((R)-2,2-Dimethyl-1-phenyl-propyl)-2-fluoro-2-phenyl-acetamide 
• 133175-45-8 (R)-N-((S)-2,2-Dimethyl-1-phenyl-propyl)-2-fluoro-2-phenyl-acetamide 
• 90495-16-2 (2,2-dimethyl-1-phenylpropyl)sulfinylamine 
• 165055-05-0 N-CBZ-β-benzyl-L-aspartyl-D-alanine (R,S)-α-tert-butylbenzylamide 
• 229613-81-4 Pd(α-tert-butylbenzylamine)2Cl2 
• 849753-47-5 rac-di-μ-chlorobis[2-(1-amino-2,2-dimethylpropyl)phenyl-C,N]dipalladium(II) 
• 938-16-9 2,2-dimethylpropiophenone 
• 82729-98-4 (1S)-α-(1,1-dimethylethyl)benzenemethanamine 
• 1007-26-7 (2,2-dimethyl-1-propyl)benzene 
• 1021189-91-2 chlorobis[2-(1-(amino)benzyl)phenyl-C,N](1-phenyl-2,2-dimethylpropylamine-N)palladium(II) 

Relevant articles and documents

New homochiral ortho-palladated matrix bearing a bulky substituent at the carbon stereocenter

A new homochiral dimeric ortho-palladated complex bearing a bulky tert-butyl substituent at the carbon stereocenter was synthesized from optically active N,N-dimethyl-α-tert-butylbenzylamine. Regioselective activation of only the aromatic C-H bond was sho

Bulky chiral carbene ligands and their application in the palladium- catalyzed asymmetric intramolecular α-arylation of amides

(Chemical Equation Presented) Bring on the big cats: New, C 2-symmetric bulky N-heterocyclic carbene ligands bring major improvements in the palladium-catalyzed asymmetric intramolecular α-arylation of amides to give oxindoles (see picture, dba=trans,trans- dibenzylideneacetone), which are formed in high yield and excellent enantiomeric purity.

Steric promotion of aromatic C-H bond activation in primary benzylamines

ortho-Palladation of a sterically crowded primary benzylamine, α- phenylneopentylamine, was accomplished in a moderate yield of 50% in the reaction with the weakest of palladation agents (Li2PdCl4) under very mild conditions, due to