63762-79-8 Usage
Description
2-Fluoro-5-methylphenol is a fluorinated aromatic compound characterized by the presence of a fluorine atom and a methyl group attached to a phenol structure. It exhibits chemical properties of a clear yellow liquid.
Uses
Used in Alkyne Metathesis:
2-Fluoro-5-methylphenol is used as an additive in the alkyne metathesis process for enhancing the efficiency and selectivity of the reaction. Its fluorinated nature contributes to the improved performance of the metathesis catalysts, leading to better outcomes in the synthesis of various organic compounds.
Used in Chemical Synthesis:
2-Fluoro-5-methylphenol serves as a valuable building block in the synthesis of a wide range of organic molecules, including pharmaceuticals, agrochemicals, and advanced materials. Its unique combination of fluorine and aromatic structures allows for versatile reactivity and functional group manipulation in organic synthesis.
Used in Material Science:
In the field of material science, 2-Fluoro-5-methylphenol can be utilized as a component in the development of novel materials with specific properties, such as improved thermal stability, chemical resistance, or enhanced electronic characteristics. Its fluorinated aromatic structure can contribute to the desired attributes of the final material.
Used in Pharmaceutical Industry:
2-Fluoro-5-methylphenol may also find applications in the pharmaceutical industry as a key intermediate in the synthesis of various drug molecules. The presence of the fluorine atom can significantly influence the pharmacokinetic and pharmacodynamic properties of the resulting compounds, potentially leading to improved drug candidates.
Used in Agrochemicals:
In the agrochemical industry, 2-Fluoro-5-methylphenol can be employed as a starting material or intermediate in the synthesis of new pesticides, herbicides, or insecticides. The introduction of the fluorine atom can enhance the biological activity and selectivity of these agrochemicals, leading to more effective and environmentally friendly products.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 33, p. 2408, 1990 DOI: 10.1021/jm00171a014
Check Digit Verification of cas no
The CAS Registry Mumber 63762-79-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,7,6 and 2 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 63762-79:
(7*6)+(6*3)+(5*7)+(4*6)+(3*2)+(2*7)+(1*9)=148
148 % 10 = 8
So 63762-79-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H13F3N2/c12-11(13,14)9-3-1-2-4-10(9)16-7-5-15-6-8-16/h1-4,15H,5-8H2
63762-79-8Relevant articles and documents
Phenol compound ortho-position direct fluorination method
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Paragraph 0049-0051, (2020/04/17)
The invention relates to a phenol compound ortho-position direct fluorination method which comprises the following steps: reacting a phenol compound shown in a formula (1A) with a fluorination reagentin a solvent under the action of a photocatalyst and a light source at room temperature, and separating and purifying a reaction mixture after the reaction to obtain a fluorinated phenol compound shown in a formula (2A). The advantages are as follows: the method for directly fluorinating phenol by organic photocatalysis is simple in operation process; raw materials are commercialized and easy toobtain; the photocatalyst is low in price, easy to obtain and environmentally friendly; the reaction condition is mild; the site selectivity is high; the reaction is efficient; and a fluorinated phenol derivative can be prepared only through one step.
Synthesis and Dopamine Receptor Affinities of 2-(4-fluoro-3-hydroxyphenyl)ethylamine and N-Substituted Derivatives
Claudi, Francesco,Cardellini, Mario,Cingolani, Gian Mario,Piergentili, Alessandro,Pertuzzi, Guidubaldo,Balduini, Walter
, p. 2408 - 2412 (2007/10/02)
The synthesis of 2-(4-fluoro-3-hydroxyphenyl)ethylamine (26) and of some N,N-dialkyl derivatives (27-30) starting from 4-fluoro-3-hydroxytoluene and their in vitro binding affinities for dopamine (DA) receptor are reported.The amine 26 can be regarded as
DIRECT FLUORINATION OF PHENOL AND CRESOLS
Misaki, Susumu
, p. 159 - 172 (2007/10/02)
A study has been made of the reaction of phenol with elemental fluorine using a variety of solvents and reaction temperatures.Yields of o- and p-fluorophenol were obtained as high as 85percent.The isomer ratio changed drastically between phenol conversions of 10percent and 56percent.The o-isomer changed to unidentified polymeric substances at higher conversion, but it might also be assumed that interconversion of some isomers is occuring.The three cresols have also been succesfully fluorinated with elemental fluorine. p-Cresol gave some expected 2-fluoroderivative but also formed a fluorocyclohexadienyl ketone.
