63795-90-4Relevant articles and documents
Enantioselective β-Protonation by a Cooperative Catalysis Strategy
Wang, Michael H.,Cohen, Daniel T.,Schwamb, C. Benjamin,Mishra, Rama K.,Scheidt, Karl A.
, p. 5891 - 5894 (2015/05/27)
An enantioselective N-heterocyclic carbene (NHC)-catalyzed β-protonation through the orchestration of three distinct organocatalysts has been developed. This cooperative catalyst system enhances both yield and selectivity, compared to only the NHC-catalyz
Preparation of β-substituted γ-keto esters by the grignard reaction on N-acylpyrazoles
Kashima, Choji,Shirahata, Yoshie,Tsukamoto, Yoshihiro
, p. 309 - 317 (2007/10/03)
Various γ-keto esters were prepared by either the alcoholysis of N-(4-oxoalkanoyl)pyrazoles or the Grignard replacement of pyrazole moiety of 4-(N-pyrazolyl)-4-oxoalkanoic esters. By using 3-phenyl-ι-menthopyrazole as a chiral auxiliary, β-substituted γ-keto esters were enantioselectively obtained.
Electroreductive acylation of activated olefins using a reactive metal anode
Ohno, Toshinobu,Aramaki, Hideo,Nakahiro, Hideki,Nishiguchi, Ikuzo
, p. 1943 - 1952 (2007/10/03)
Electroreductive acylation of 3-aryl substituted α,β-unsaturated esters and nitriles in the presence of aliphatic carboxylic anhydrides using reactive metal anode (Mg, Al, Zn) in an undivided cell afforded the corresponding β-acyl compounds in moderate to good yields. It was found that anionic species formed by electron transfer from a cathode may be stabilized by metal ions freshly formed from an anode and undergo electrophilic attack of carboxylic anhydrides to give the β-acyl products in high yields as compared with the previously reported method using a divided cell.
