70030-52-3

Basic information

• Product Name: 2-Propenethioic acid, 3-phenyl-, S-phenyl ester, (2E)-
• CAS NO: 70030-52-3
• Molecular Formula: C15H12OS
• Molecular Weight: 240.326
• Mol File: 70030-52-3.mol
• Article Data: 37

Chemical Properties

• CAS DataBase Reference: 2-Propenethioic acid, 3-phenyl-, S-phenyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenethioic acid, 3-phenyl-, S-phenyl ester, (2E)-(70030-52-3)
• EPA Substance Registry System: 2-Propenethioic acid, 3-phenyl-, S-phenyl ester, (2E)-(70030-52-3)

Safety Data

• Hazardous Substances Data: 70030-52-3(Hazardous Substances Data)

Upstream product

• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 4551-15-9 phenylthiotrimethylsilane 
• 53963-28-3 (E)-1-phenyl-3,3-bis(phenylthio)propene 
• 27610-20-4 substituted benzenethiol 
• 102-92-1 Cinnamoyl chloride 
• 201230-82-2 carbon monoxide 
• 108-98-5 thiophenol 
• 536-74-3 phenylacetylene 
• 13939-06-5 molybdenum hexacarbonyl 
• 140-10-3 cis-cinnamic acid 
• 71-43-2 benzene 
• 140-10-3 (E)-3-phenylacrylic acid 
• 103-64-0 bromostyrene 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 

Downstream Products

• 136504-84-2 syn-2-(phenylmethyl)-3-hydroxy-3-phenylthiopropanoic acid S-phenyl ester 
• 136504-84-2 anti-2-(phenylmethyl)-3-hydroxy-3-phenylthiopropanoic acid S-phenyl ester 
• 1075-14-5 2H-thiochromen-2-one 
• 1313870-27-7 (R)-ethyl 6-methyl-2-oxo-4-phenyl-3,4-dihydro-2H-pyran-5-carboxylate 
• 1331750-78-7 (S)-ethyl 6-methyl-2-oxo-4-phenyl-3,4-dihydro-2H-pyran-5-carboxylate 
• 7214-56-4 phenyl(styryl)sulfane 
• 7214-53-1 (E)-[2-(phenylsulfanyl)vinyl]benzene 
• 14990-09-1 tert-butyl cinnamate 
• 491-39-4 thiochromen-4-one 
• 108-98-5 thiophenol 
• 621-82-9 Cinnamic acid 
• 784-62-3 1-thioflavone 
• 5962-00-5 2-phenyl-thiochroman-4-one 
• 139-66-2 diphenyl sulfide 

Relevant articles and documents

Ligand-Controlled Regiodivergent Thiocarbonylation of Alkynes toward Linear and Branched α,β-Unsaturated Thioesters

Thiocarbonylation of alkynes offers an ideal procedure for the synthesis of unsaturated thioesters. A robust ligand-controlled regioselective thiocarbonylation of alkynes is developed. Utilizing boronic acid and 5-chlorosalicylic acid as the acid additive to in situ form 5-chloroborosalicylic acid (5-Cl-BSA), and bis(2-diphenylphosphinophenyl)ether (DPEphos) as the ligand, linear α,β-unsaturated thioesters were produced in a straightforward manner. Switching the ligand to tri(2-furyl)phosphine can turn the reaction selectivity to give branched products. Remarkably, this approach also represents the first example on thiocarbonylation of internal alkynes.

Catalytic Enantioselective Conjugate Addition of Stereodefined Di- and Trisubstituted Alkenylaluminum Compounds to Acyclic Enones

Catalytic enantioselective conjugate addition (ECA) reactions with readily accessible and stereochemically defined E-, Z-, di- and trisubstituted alkenyl aluminum compounds are disclosed. Transformations are promoted by various NHC-copper catalysts (NHC=N-heterocyclic carbene), which are derived from enantiomerically pure sulfonate imidazolinium salts. The desired products were obtained in up to 89% yield and >99:1 e.r.; the alkenyl moiety was transferred with complete retention of its stereochemical identity in all instances. The scope and limitations of the approach, key mechanistic attributes, and representative functionalization are presented as well. (Figure presented.).

Decarbonylative thioetherification by nickel catalysis using air- and moisture-stable nickel precatalysts

A general, highly selective method for decarbonylative thioetherification of aryl thioesters by C-S cleavage is reported. These reactions are promoted by a commercially-available, user-friendly, inexpensive, air- and moisture-stable nickel precatalyst. The process occurs with broad functional group tolerance, including free anilines, cyanides, ketones, halides and aryl esters, to efficiently generate thioethers using ubiquitous carboxylic acids as ultimate cross-coupling precursors (cf. conventional aryl halides or pseudohalides). Selectivity studies and site-selective orthogonal cross-coupling/thioetherification are described. This thioester activation/coupling has been highlighted in the expedient synthesis of biorelevant drug analogue. In light of the synthetic utility of thioethers and Ni(ii) precatalysts, we anticipate that this user-friendly method will be of broad interest.