75893-82-2

Basic information

• Product Name: 6-FLUORO-3,4-DIHYDROQUINOLIN-2(1H)-ONE
• Synonyms: 6-FLUORO-3,4-DIHYDROQUINOLIN-2(1H)-ONE;6-FLUORO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE;6-fluoro-3,4-dihydro-2(1H)-quinolinone(SALTDATA: FREE);6-fluoro-1,2,3,4-tetrahydroquinolin-2-one;6-fluoro-3,4-dihydrocarbostyril;3,4-Dihydro-6-fluoro-2(1H)-quinolinone;6-Fluoro-2-oxo-1,2,3,4-tetrahydroquinoline;6-fluoro-3,4-dihydro-2(1H)-quinolinone
• CAS NO: 75893-82-2
• Molecular Formula: C₉H₈FNO
• Molecular Weight: 165.17
• EINECS: 604-604-1
• Mol File: 75893-82-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 323.5 °C at 760 mmHg
• Flash Point: 149.5 °C
• Appearance: /
• Density: 1.241 g/cm³
• CAS DataBase Reference: 6-FLUORO-3,4-DIHYDROQUINOLIN-2(1H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUORO-3,4-DIHYDROQUINOLIN-2(1H)-ONE(75893-82-2)
• EPA Substance Registry System: 6-FLUORO-3,4-DIHYDROQUINOLIN-2(1H)-ONE(75893-82-2)

Safety Data

• Hazardous Substances Data: 75893-82-2(Hazardous Substances Data)

Usage

General Description

6-FLUORO-3,4-DIHYDROQUINOLIN-2(1H)-ONE is a chemical compound with the molecular formula C9H7NOF. It is a fluorinated derivative of dihydroquinolinone and belongs to the quinoline class of compounds. This chemical is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and biologically active compounds. Its unique structure and fluorine substitution make it an important intermediate in the development of pharmaceuticals with potential therapeutic applications. Studies have also shown that 6-FLUORO-3,4-DIHYDROQUINOLIN-2(1H)-ONE has antimicrobial and antifungal properties, making it a potentially valuable component in the development of new antimicrobial agents.

Upstream product

• 771-19-7 1-hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline 
• 61272-76-2 4-fluoro-2-iodoaniline 
• 140-88-5 ethyl acrylate 
• 371-40-4 4-fluoroaniline 
• 56767-37-4 3-chloro-N-(4-fluorophenyl)propionamide 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 772-70-3 3-(4-fluorophenyl)propanoyl chloride 
• 459-31-4 3-(4-fluorophenyl)propanoic acid 

Downstream Products

• 59611-52-8 6-fluoro-1,2,3,4-tetrahydroquinoline 
• 1610667-34-9 1-benzyl-6-fluoro-3.4-dihydroquinolin-2(1H)-one 
• 22614-75-1 6-fluoro-1H-quinolin-2-one 
• 792122-31-7 6-fluoro-3-(3-methylamino-propyl)-1-p-tolyl-3,4-dihydro-1H-quinolin-2-one 

Relevant articles and documents

Ruthenium-catalyzed intramolecular arene C(sp2)-H amidation for synthesis of 3,4-dihydroquinolin-2(1 H)-ones

We report the [Ru(p-cymene)(l-proline)Cl] ([Ru1])-catalyzed cyclization of 1,4,2-dioxazol-5-ones to form dihydroquinoline-2-ones in excellent yields with excellent regioselectivity via a formal intramolecular arene C(sp2)-H amidation. The reactions of the 2- and 4-substituted aryl dioxazolones proceeds initially through spirolactamization via electrophilic amidation at the arene site, which is para or ortho to the substituent. A Hammett correlation study showed that the spirolactamization is likely to occur by electrophilic nitrenoid attack at the arene, which is characterized by a negative ρ value of -0.73.

Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model

Histone deacetylase 6 (HDAC6) is a promising therapeutic target for the treatment of neurodegenerative disorders. SW-100 (1a), a phenylhydroxamate-based HDAC6 inhibitor (HDAC6i) bearing a tetrahydroquinoline (THQ) capping group, is a highly potent and sel

Regiodivergent access to five- and six-membered benzo-fused lactams: Ru-catalyzed olefin hydrocarbamoylation

We report herein a new strategy of the Ru-catalyzed intramolecular olefin hydrocarbamoylation for the regiodivergent synthesis of five- and six-membered benzo-fused lactams starting from N-(2-alkenylphenyl)formamides. Using a combined catalyst of Ru3