4-Methoxy-N-ethylbenzamide

Base Information

• Chemical Name: 4-Methoxy-N-ethylbenzamide
• CAS No.: 7403-41-0
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Mol file: 7403-41-0.mol

Synonyms:N-ethyl-4-methoxy-benzamide;Benzamide,N-ethyl-4-methoxy;p-methoxybenzoylethylamide;N-ethyl-4-methoxyphenylcarboxamide;4-Methoxy-N-aethyl-benzamid;4-Methoxy-benzoesaeure-aethylamid;4-methoxy-benzoic acid ethylamide;

Chemical Property of 4-Methoxy-N-ethylbenzamide

Chemical Property:

• Vapor Pressure: 0.000129mmHg at 25°C
• Melting Point: 71-72 °C
• Boiling Point: 334.3°Cat760mmHg
• PKA: 15.13±0.46(Predicted)
• Flash Point: 156°C
• PSA: 38.33000
• Density: 1.052g/cm³
• LogP: 1.83580

Purity/Quality:

99% ^*data from raw suppliers

N-ETHYL-4-METHOXYBENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methoxy-N-ethylbenzamide

There total 20 articles about 4-Methoxy-N-ethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methoxyphenylacetamide (3424-93-9) + triethyl((3-ethylpent-3-yl)peroxy)silane → N-ethyl-4-methoxy-benzamide (7403-41-0)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; In benzene; at 60 ℃; for 11h; Inert atmosphere;

DOI:10.1002/chem.201702217

Reference yield: 94.0%

dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) + ethylamine (75-04-7,85404-22-4) → N-ethyl-4-methoxy-benzamide (7403-41-0)

Guidance literature:

With dmap; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 90 ℃; for 0.333333h; Sealed tube; Microwave irradiation;

DOI:10.1016/j.tetlet.2013.12.062

Reference yield: 94.0%

dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) + ethylamine (75-04-7,85404-22-4) → N-ethyl-4-methoxy-benzamide (7403-41-0)

Guidance literature:

With dmap; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 90 ℃; for 0.333333h; Solvent; Microwave irradiation;

DOI:10.1016/j.tetlet.2013.12.062

upstream raw materials:

p-methoxybenzoyl fluoride

ethylamine

p-nitrophenyl p-methoxybenzoate

2,4-dinitrophenyl 4-methoxybenzoate

Downstream raw materials:

acetyl-p-methoxybenzoylimide

N-ethyl-4-methoxybenzenemethanamine

4-Methoxybenzyl alcohol

N-(4-methoxybenzyl)ethylamine hydrochloride

Refernces

• 1、 -. "Method for synthesizing amide by using methyl arene and amine in water phase". Paragraph 0015; 0053-0056. . Retrieved 2021/03/06.
• 2、 Ghosh, Santanu,Jana, Chandan K.. "Metal-Free Thermal Activation of Molecular Oxygen Enabled Direct α-CH2-Oxygenation of Free Amines". . p. 260 - 266. Retrieved 2018/02/19.