5-Pyridin-2-yl-1,3,4-oxadiazol-2-amine

Base Information

• Chemical Name: 5-Pyridin-2-yl-1,3,4-oxadiazol-2-amine
• CAS No.: 5711-72-8
• Molecular Formula: C7H6N4O
• Molecular Weight: 162.15
• Hs Code.: 2934999090
• European Community (EC) Number: 671-481-8
• DSSTox Substance ID: DTXSID20205737
• Nikkaji Number: J42.562A
• Wikidata: Q83079383
• Mol file: 5711-72-8.mol

Synonyms:5711-72-8;5-pyridin-2-yl-1,3,4-oxadiazol-2-amine;5-(pyridin-2-yl)-1,3,4-oxadiazol-2-amine;5-Pyridin-2-yl-1,3,4-oxadiazol-2-ylamine;BRN 0975839;2-Amino-5-(2-pyridyl)-1,3,4-oxadiazole;1,3,4-OXADIAZOLE, 2-AMINO-5-(2-PYRIDYL)-;SCHEMBL2160834;DTXSID20205737;AOD100484;BBL029453;MFCD01710636;STL221352;AKOS000124296;(R)-1-(4-tert-Butylphenyl)ethylamine;CCG-309990;FS-3888;LS-99079;5-(2-Pyridyl)-1,3,4-oxadiazol-2-amine;5-(2-pyridinyl)-1,3,4-oxadiazol-2-amine;CS-0071815;5-(pyridin-2-yl)-1,3,4-oxadiazol-2-ylamine;A19890;D95021;EN300-236123;A831318;Pyridine, 2-(5-amino-1,3,4-oxadiazol-2-yl)-;F2182-0118

Chemical Property of 5-Pyridin-2-yl-1,3,4-oxadiazol-2-amine

Chemical Property:

• Vapor Pressure: 9.17E-06mmHg at 25°C
• Melting Point: 265-268 °C
• Refractive Index: 1.614
• Boiling Point: 373.1 °C at 760 mmHg
• PKA: -1.08±0.19(Predicted)
• Flash Point: 179.5 °C
• PSA: 77.83000
• Density: 1.357 g/cm³
• LogP: 1.29500
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 162.05416083
• Heavy Atom Count: 12
• Complexity: 154

Purity/Quality:

98%Min ^*data from raw suppliers

5-Pyridin-2-yl-1,3,4-oxadiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C2=NN=C(O2)N

Technology Process of 5-Pyridin-2-yl-1,3,4-oxadiazol-2-amine

There total 7 articles about 5-Pyridin-2-yl-1,3,4-oxadiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(pyridin-2-ylmethylidene)hydrazinecarboxamide (13370-79-1) → 2-amino-5-(pyridin-2-yl)-1,3,4-oxadiazole (5711-72-8)

Guidance literature:

With lithium perchlorate; acetic acid; at 25 ℃; for 5h; Electrochemical reaction;

Reference yield: 45.0%

(E)-2-(pyridin-2-ylmethylene)hydrazinecarbothioamide (61043-10-5) → 2-amino-5-(pyridin-2-yl)-1,3,4-oxadiazole (5711-72-8)

Guidance literature:

With potassium bromate; sulfuric acid; In water; pH=0 - 1;

DOI:10.1002/ejic.200200689

Reference yield:

picolinic acid hydrazide (1452-63-7) + bromocyane (506-68-3) → 2-amino-5-(pyridin-2-yl)-1,3,4-oxadiazole (5711-72-8)

Guidance literature:

With water; potassium hydrogencarbonate; In 1,4-dioxane; for 15h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmc.2013.08.048

upstream raw materials:

(2-picoloylcarbonyl)thiosemicarbazone

2-Picolinic acid

hydrazine carboxamide

(E)-2-(pyridin-2-ylmethylene)hydrazinecarbothioamide

Refernces

• 1、 Naclerio, George A.,Abutaleb, Nader S.,Li, Daoyi,Seleem, Mohamed N.,Sintim, Herman O.. "Ultrapotent Inhibitor of Clostridioides difficile Growth, Which Suppresses Recurrence in Vivo". . p. 11934 - 11944. Retrieved 2020/11/26.
• 2、 Sanjeev, Kumar,Srivastava. "A green approach for the synthesis of biologically active heterocyclic compounds at the platinum electrode". . p. 1019 - 1026. Retrieved 2013/09/23.