2-propyl-4-phenylquinazoline

Base Information

• Chemical Name: 2-propyl-4-phenylquinazoline
• CAS No.: 107288-96-0
• Molecular Formula: C₁₇H₁₆N₂
• Molecular Weight: 248.327
• Mol file: 107288-96-0.mol

Synonyms:2-propyl-4-phenylquinazoline

Chemical Property of 2-propyl-4-phenylquinazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-propyl-4-phenylquinazoline

There total 9 articles about 2-propyl-4-phenylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

o-bromobenzophenone (13047-06-8) + butylamidine hydrochloride (3020-81-3) → 2-propyl-4-phenylquinazoline (107288-96-0)

Guidance literature:

o-bromobenzophenone; butylamidine hydrochloride; With caesium carbonate; L-proline; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

With copper(l) iodide; In N,N-dimethyl-formamide; at 20 - 110 ℃; for 24h; Inert atmosphere;

DOI:10.1039/b814011a

Reference yield: 61.0%

C18H18N2O3S (1448311-40-7) + triphenylindium (3958-47-2) → 2-propyl-4-phenylquinazoline (107288-96-0)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris(2-thienyl)phosphine; In tetrahydrofuran; at 60 ℃; for 4h; Inert atmosphere;

DOI:10.1055/s-0035-1562504

Reference yield: 58.0%

2-propyl-3H-quinazolin-4-one (4765-54-2) + phenylboronic acid (98-80-6) → 2-propyl-4-phenylquinazoline (107288-96-0)

Guidance literature:

2-propyl-3H-quinazolin-4-one; With sodium ethanolate; p-toluenesulfonyl chloride; In 1,4-dioxane; at 70 ℃; for 0.333333h;

phenylboronic acid; With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; In 1,4-dioxane;

DOI:10.14233/ajchem.2017.20513

upstream raw materials:

N-(2-benzoylphenyl)butyramide

butyryl chloride

anthranilic acid nitrile

(2-aminophenyl)(phenyl)methanone

Refernces

• 1、 Prakash, Rashmi,Bora, Bidisha R.,Boruah, Romesh C.,Gogoi, Sanjib. "Ru(II)-Catalyzed C-H Activation and Annulation Reaction via Carbon-Carbon Triple Bond Cleavage". supporting information. p. 2297 - 2300. Retrieved 2018/04/30.
• 2、 Qiu, Guanyinsheng,Huang, Ping,Yang, Qin,Lu, Hui,Xu, Jingshi,Deng, Zhihong,Zhang, Ming,Peng, Yiyuan. "Synthesis of 4-arylquinazolines by arylation of quinazolin-4-ones under mild conditions". . p. 3131 - 3136. Retrieved 2013/12/04.