134747-51-6

Basic information

• Product Name: trans-1-(4-fluorophenyl)-3-phenylprop-2-en-1-ol
• Synonyms: trans-1-(4-fluorophenyl)-3-phenylprop-2-en-1-ol
• CAS NO: 134747-51-6
• Molecular Weight: 228.266
• Mol File: 134747-51-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: trans-1-(4-fluorophenyl)-3-phenylprop-2-en-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: trans-1-(4-fluorophenyl)-3-phenylprop-2-en-1-ol(134747-51-6)
• EPA Substance Registry System: trans-1-(4-fluorophenyl)-3-phenylprop-2-en-1-ol(134747-51-6)

Safety Data

• Hazardous Substances Data: 134747-51-6(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 98-86-2 acetophenone 
• 22966-25-2 (E)-1-(4-fluorophenyl)-3-phenyl-2-propen-1-one 
• 142739-41-1 1-(4-fluorophenyl)-3-phenylprop-2-yn-1-ol 
• 536-74-3 phenylacetylene 
• 399-10-0 4'-fluorochalcone 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 100-52-7 benzaldehyde 
• 14371-10-9 (E)-3-phenylpropenal 
• 203664-74-8 diethyl benzylsulfonylmethylphosphonate 
• 889862-10-6 trans-1-benzylsulfonyl-2-(4-fluorophenyl)ethene 

Downstream Products

• 87639-09-6 rac-(E)-1-(4-fluorophenyl)-3-phenylallyl acetate 
• 87639-10-9 1-Fluoro-4-[1-((E)-styryl)-but-3-ynyl]-benzene 
• 1260861-95-7 1-(4-morpholinophenyl)-3-phenylpropan-1-one 
• 41938-64-1 1-(4-fluorophenyl)-3-phenylpropan-1-one 
• 399-10-0 4'-fluorochalcone 
• 485844-19-7 1-fluoro-4-[(2E)-3-phenyl-2-propen-1-yl]benzene 
• 183621-32-1 (E)-1-fluoro-4-(3-phenylprop-1-en-1-yl)benzene 

Relevant articles and documents

Potassium Base-Promoted Diastereoselective Synthesis of 1,3-Diols from Allylic Alcohols and Aldehydes through a Tandem Allylic-Isomerization/Aldol–Tishchenko Reaction

This study reports the first base-promoted aldol–Tishchenko reactions of allylic alcohols with aldehydes initiated by allylic isomerization. The reaction enables the diastereoselective synthesis of a variety of 1,3-diols with three contiguous stereogenic centers. Unlike commonly reported systems, our method allows the use of readily available allylic alcohols as nucleophiles instead of enolizable aldehydes and ketones.

NaH mediated isomerisation-allylation reaction of 1,3-substituted propenols

A base mediated isomerisation-allylation protocol of 1,3-disubstituted propenols has been established. The use of diaryl and aryl-silyl substrates is reported alongside the use of substituted allyl bromides. Mechanistic experiments have also been conducted to elucidate the reaction pathway. The Royal Society of Chemistry 2013.

The epoxy-Ramberg-Baecklund reaction (ERBR): A sulfone-based method for the synthesis of allylic alcohols

The epoxy-Ramberg-Baecklund reaction (ERBR) is outlined, in which α,β-epoxy sulfones are converted into a range of mono-, di- and tri-substituted allylic alcohols, on treatment with base. Modification of this method enabled the preparation of enantio-enriched allylic alcohols following the diastereoselective epoxidation of enantio-enriched vinyl sulfones that were accessed efficiently from the chiral pool. The scope, optimisation and limitations of the ERBR as a method for the preparation of allylic alcohols are discussed. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.